{"id":10459,"date":"2021-05-26T12:31:07","date_gmt":"2021-05-26T09:31:07","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=10459"},"modified":"2021-05-26T12:31:10","modified_gmt":"2021-05-26T09:31:10","slug":"telomerazin-kasifi-elizabeth-blackburn","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/telomerazin-kasifi-elizabeth-blackburn\/","title":{"rendered":"TELOMERAZIN K\u00c2\u015e\u0130F\u0130: EL\u0130ZABETH BLACKBURN"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" width=\"1024\" height=\"1024\" src=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-1024x1024.jpg\" alt=\"\" class=\"wp-image-10460\" srcset=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-1024x1024.jpg 1024w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-150x150.jpg 150w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-250x250.jpg 250w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-125x125.jpg 125w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-110x110.jpg 110w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-420x420.jpg 420w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-1536x1536.jpg 1536w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-2048x2048.jpg 2048w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001-768x768.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>https:\/\/commons.wikimedia.org\/wiki\/File:Elizabeth_Blackburn_CHF_Heritage_Day_2012_Rush_001.JPG<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"has-drop-cap has-medium-font-size\">Molek\u00fcler biyolog ve biyokimyac\u0131 olan Elizabeth Blackburn, telomer ve telomerazla ilgili \u00e7al\u0131\u015fmalar\u0131yla genetik bilimine \u00f6nemli katk\u0131lar\u0131 olan bir bilim insan\u0131d\u0131r.<br><\/p>\n\n\n\n<p class=\"has-text-align-center has-vivid-green-cyan-color has-text-color has-medium-font-size\"><strong>\u00d6zel Ya\u015fam\u0131 ve E\u011fitim Hayat\u0131<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size\">\u0130ki aile doktorunun k\u0131z\u0131 olarak 26 Kas\u0131m 1948\u2019de Avustralya\u2019da do\u011fdu. Canl\u0131lara ve do\u011faya d\u00fc\u015fk\u00fcnl\u00fc\u011f\u00fc \u00e7ocuklu\u011fundan ba\u015flad\u0131. \u00c7ocukken okudu\u011fu ve etkilendi\u011fi Marie Curie\u2019nin biyografisi ve lisedeki \u00f6\u011fretmenlerinin biyolojiye olan ilgisini desteklemesi sonucu Melbourne \u00dcniversitesi\u2019nde biyokimya b\u00f6l\u00fcm\u00fcne ba\u015flad\u0131. Y\u00fcksek lisans\u0131n\u0131 da ayn\u0131 \u00fcniversitede biyokimya \u00fczerine yapt\u0131.<\/p>\n\n\n\n<p class=\"has-medium-font-size\">Y\u00fcksek lisans derecesini ald\u0131ktan sonra Cambridge \u00dcniversitesinde molek\u00fcler biyoloji alan\u0131nda doktora e\u011fitimine ba\u015flad\u0131. E\u015fiyle burada tan\u0131\u015ft\u0131. 1975\u2019te e\u015finin planlar\u0131ndan dolay\u0131 ABD\u2019ye ta\u015f\u0131nd\u0131 ve Yale\u2019de molek\u00fcler ve h\u00fccresel biyoloji \u00fczerine doktora sonras\u0131 e\u011fitimine ba\u015flad\u0131 ve <em>Tetrahymena<\/em> (bir protozoa cinsi) kromozomlar\u0131 \u00fczerinde genetik \u00e7al\u0131\u015fmalar yapt\u0131.<\/p>\n\n\n\n<p class=\"has-text-align-center has-vivid-green-cyan-color has-text-color has-medium-font-size\"><strong>Telomeraz\u0131n Ke\u015ffi<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size\">Doktora sonras\u0131 e\u011fitimini bitirince San Francisco\u2019ya ta\u015f\u0131nd\u0131. 1978\u2019de Berkeley&#8217;deki California \u00dcniversitesi&#8217;nde Molek\u00fcler Biyoloji B\u00f6l\u00fcm\u00fcnde \u00e7al\u0131\u015fmaya ba\u015flad\u0131. Burada da Tetrahymena \u00fczerinde \u00e7al\u0131\u015fmaya devam ederek telomer ve ili\u015fkili proteinler \u00fczerine ara\u015ft\u0131rmalar yapt\u0131. Ara\u015ft\u0131rmalar\u0131nda telomerlerin \u00f6zel bir DNA\u2019ya sahip oldu\u011funu ke\u015ffetti.<\/p>\n\n\n\n<p class=\"has-medium-font-size\">1980 y\u0131l\u0131nda Jack Szostak ile tan\u0131\u015ft\u0131. O da telomerler \u00fczerine \u00e7al\u0131\u015f\u0131yordu. \u0130kili beraber \u00e7al\u0131\u015fmaya ba\u015flad\u0131 ve 1982\u2019de telomer DNA\u2019s\u0131n\u0131n kromozomlar\u0131n par\u00e7alanmas\u0131n\u0131 engelledi\u011fini kan\u0131tlad\u0131.<\/p>\n\n\n\n<p class=\"has-medium-font-size\">1984 y\u0131l\u0131nda ise Blackburn, \u00f6\u011frencisi Carol Greider ile &nbsp;telomeraz enzimini ke\u015ffetti ve sonraki \u00e7al\u0131\u015fmalar\u0131 da bu enzimin telomerlere DNA ekleyerek kromozomlar\u0131 korudu\u011funu g\u00f6sterdi.<\/p>\n\n\n\n<p class=\"has-medium-font-size\">Blackburn, kromozomlar\u0131n telomerler ve enzim telomeraz taraf\u0131ndan nas\u0131l korundu\u011funun ke\u015ffi dolay\u0131s\u0131yla 2009 Nobel T\u0131p veya Fizyoloji \u00d6d\u00fcl\u00fc\u2019ne Greider ve Szostak ile birlikte lay\u0131k g\u00f6r\u00fcld\u00fc.<br><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" width=\"1200\" height=\"541\" src=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn.jpg\" alt=\"\" class=\"wp-image-10462\" srcset=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn.jpg 1200w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn-400x180.jpg 400w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn-1024x462.jpg 1024w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn-768x346.jpg 768w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn-110x50.jpg 110w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn-420x189.jpg 420w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2021\/05\/1200px-Carol_Greider_and_Elizabeth_Blackburn-770x347.jpg 770w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><figcaption>Elizabeth Blackburn, Carol Greider (solda) ile birlikte<br>https:\/\/commons.wikimedia.org\/wiki\/File:Carol_Greider_and_Elizabeth_Blackburn.JPG<\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"has-medium-font-size\">\u00c7al\u0131\u015fmalar\u0131na telomerlerin ile telomeraz\u0131n genetik bile\u015fimi ve h\u00fccresel i\u015flevlerinin daha ayr\u0131nt\u0131l\u0131 \u015fekilde ara\u015ft\u0131rarak devam etti. Ayr\u0131ca kanser ve ya\u015flanma \u00fczerine \u00e7ok say\u0131da \u00e7al\u0131\u015fma yapt\u0131. <br>Blackburn \u015fu anda San Francisco\u2019daki Kaliforniya \u00dcniversitesi\u2019nde Biyokimya ve Biyofizik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesidir.<\/p>\n\n\n\n<p class=\"has-black-color has-vivid-green-cyan-background-color has-text-color has-background has-medium-font-size\">Elizabeth Blackburn&#8217;un telomer hakk\u0131ndaki TED konu\u015fmas\u0131n\u0131 buradan izleyebilirsiniz:<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"The science of cells that never get old | Elizabeth Blackburn\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/2wseM6wWd74?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"has-text-align-center has-vivid-green-cyan-color has-text-color has-medium-font-size\"><strong>Kaynaklar:<\/strong><\/p>\n\n\n\n<ul><li>Elizabeth H. Blackburn Biographical https:\/\/www.nobelprize.org\/prizes\/medicine\/2009\/blackburn\/biographical\/<\/li><li>Elizabeth H. Blackburn Facts https:\/\/www.nobelprize.org\/prizes\/medicine\/2009\/blackburn\/facts\/<\/li><li>Elizabeth H. Blackburn https:\/\/www.britannica.com\/biography\/Elizabeth-Blackburn<\/li><li>Elizabeth Blackburn, PhD https:\/\/profiles.ucsf.edu\/elizabeth.blackburn#toc-id3<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Molek\u00fcler biyolog ve biyokimyac\u0131 olan Elizabeth Blackburn, telomer ve telomerazla ilgili \u00e7al\u0131\u015fmalar\u0131yla genetik bilimine \u00f6nemli katk\u0131lar\u0131 olan bir bilim insan\u0131d\u0131r.<\/p>\n","protected":false},"author":265,"featured_media":10461,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,6],"tags":[2056,115,453,947,2057,2058],"acf":[],"views":1328,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/10459"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/265"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=10459"}],"version-history":[{"count":8,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/10459\/revisions"}],"predecessor-version":[{"id":10545,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/10459\/revisions\/10545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/10461"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=10459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=10459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=10459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}