{"id":10500,"date":"2021-05-20T15:54:32","date_gmt":"2021-05-20T12:54:32","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=10500"},"modified":"2021-05-20T16:44:17","modified_gmt":"2021-05-20T13:44:17","slug":"alerji-ilaclari-alerjiyi-daha-da-kotulestirir-mi","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/alerji-ilaclari-alerjiyi-daha-da-kotulestirir-mi\/","title":{"rendered":"ALERJ\u0130 \u0130LA\u00c7LARI ALERJ\u0130Y\u0130 DAHA DA K\u00d6T\u00dcLE\u015eT\u0130R\u0130R M\u0130?"},"content":{"rendered":"\n
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https:\/\/www.flickr.com\/photos\/127641228@N07\/15474765550\/in\/photolist-pzsdEA-3qEy2d-TksVPL-HHFigP-oRyyt2-XB98Ur-pVJTSK-Uq9q7z-E8FpiB-GJHyUs-juCnkA-juAvT2-25HpbPs-Cbd7id-r9s7Qd-AHQFM1-eYFEA8-FDRDah-8r48Ep-8r7fG5-MCxkhY-aLv39r-FHDK4D-8r48sz-8qMxg3-aLuZzv-8r7frG-9qE8M2-8qMvRu-aLv7KX-22GMC4A-8qMv83-8qMv9q-2kYeKZv-8r7fjS-KkxvTw-7qUWt1-8r49RM-2kYdco9-HCWcgU-73qtPT-2kYdcz6-8qJph4-5PNmKW-8qJpjB-8r7gPU-8qMwvs-2kYdctz-2kYaj43-8qMwPY<\/figcaption><\/figure>\n\n\n\n

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Bahar; kimimiz i\u00e7in ye\u015filin, do\u011fan\u0131n tazelenmesinin, ne\u015fenin, belki de yeni bir ya\u015f\u0131n (benim gibi :)) m\u00fcjdesidir. \u0130\u00e7ini k\u0131p\u0131r k\u0131p\u0131r eder insan\u0131n. Kimileri i\u00e7in ise kabus olabiliyor maalesef ki. Neden mi bahsediyorum? Tabi ki bahar alerjisi. Her y\u0131l bahar\u0131n gelmesiyle birlikte alerjik hastal\u0131klar\u0131n g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131nda art\u0131\u015f g\u00f6zlenir. Bunun nedeni a\u011fa\u00e7, \u00e7i\u00e7ek, \u00e7imen ve di\u011fer bitkilerin olu\u015fturdu\u011fu polenlerdir.  Bu k\u00fc\u00e7\u00fck, kuru bitki spermlerinin \u00e7o\u011fu yanl\u0131\u015fl\u0131kla burnumuza girerek mevsimsel alerji denen ba\u011f\u0131\u015f\u0131kl\u0131k reaksiyonunu tetikliyor.<\/p>\n\n\n\n

Alerji mevsimi her y\u0131l daha k\u00f6t\u00fcye gitmekle beraber; son y\u0131llarda alerjiler %40 art\u0131\u015f g\u00f6stermi\u015ftir. Buna ba\u011fl\u0131 olarak da alerji ila\u00e7lar\u0131 her zamankinden daha fazla kullan\u0131l\u0131yor. Bu kontrols\u00fcz ila\u00e7 kullan\u0131m\u0131n\u0131n hastalar\u0131n akl\u0131na \u00e7e\u015fitli sorular getirmesi \u00e7ok ola\u011fand\u0131r.<\/p>\n\n\n\n

Her zaman alerji ila\u00e7lar\u0131 al\u0131rsam, v\u00fccudumun alerjenlere kar\u015f\u0131 tolerans geli\u015ftirmesini engeller miyim? Sadece alerjimi daha \u015fiddetli hale mi getiririm? Mevsim ilerledik\u00e7e ya da ya\u015fland\u0131k\u00e7a alerjilerim daha da k\u00f6t\u00fcle\u015fir mi? Ben bu ila\u00e7lar\u0131 kullan\u0131yorum ama hi\u00e7bir i\u015fe yaram\u0131yorlar, ne yapaca\u011f\u0131m?<\/strong> <\/p>\n\n\n\n

Bu gibi sorular\u0131m\u0131z\u0131n hedefi ila\u00e7lar olmamal\u0131d\u0131r.  Bu sorunlar \u00e7e\u015fitli durumlardan kaynakl\u0131 olabilmektedir. Alerjiyi sadece belirli bir ya\u015f grubuna indirgememek gerekir. \u00c7ocukken alerjiniz yoksa, yeti\u015fkinlik d\u00f6neminde alerji ortaya \u00e7\u0131kabilir. \u00c7ocukluk d\u00f6neminde alerjiniz varsa, alerjiniz yeti\u015fkinlik d\u00f6neminde nedeni bilinmeyen bir \u015fekilde a\u015famal\u0131 olarak kaybolabilir. Ayn\u0131 zamanda bireye \u00f6zg\u00fc durumlar da sebep olabilir. Chicago Alerji ve Ast\u0131m T\u0131bbi Direkt\u00f6r\u00fc Sarena Sawlani, her bireyin alerji ila\u00e7lar\u0131na farkl\u0131 tepki verdi\u011fini, bunun nedenlerinin ise karma\u015f\u0131k olmakla birlikte hen\u00fcz tam anla\u015f\u0131lamad\u0131\u011f\u0131n\u0131 ifade etmi\u015ftir.<\/p>\n\n\n\n

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https:\/\/www.flickr.com\/photos\/27887892@N03\/5555885421\/in\/photolist-9sXnaX-qNRnJD-Q31N-awzjf4-awCZNw-awA6ht-awCF8L-78oVit-C8hNQq-awCz3A-6FkM6L-mJrhVM-awAsnp-awzZ4T-P8zKU2-pEfpho-awA2mD-6mZae-VVc4wg-2iT949g-awzxKi-9tN8fW-awzUha-awzBin-awBYFs-DbUrpP-awCCF9-awCkFw-awDfXo-pnM2m4-awA77r-4dD9EK-awzfEx-FsMbuy-4jL8mP-UTcnRV-2gvdES9-ai9gi6-foiKm-awzYnV-awAvGZ-awzEZ8-E42V67-9EY19u-9pm6jP-PifJhv-awAyt8-awzzNc-NVWQE1-88bGU2<\/figcaption><\/figure>\n\n\n\n

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Haz\u0131r alerji ila\u00e7lar\u0131 hakk\u0131nda kafam\u0131zdaki soru i\u015faretlerinden bahsediyorken b\u00fct\u00fcn bunlar\u0131 bir kenara b\u0131rak\u0131p alerji ila\u00e7lar\u0131 nelermi\u015f k\u0131saca bir de onlara g\u00f6z atal\u0131m:<\/p>\n\n\n\n

Alerji ila\u00e7lar\u0131n\u0131 iki ana ba\u015fl\u0131k alt\u0131nda toplayabiliriz: Antihistaminikler ve kortikosteroidler.<\/p>\n\n\n\n

 Mast h\u00fccreleri, bir alerjeni tespit eder etmez, b\u00fcy\u00fck miktarlarda histamin salg\u0131lar. Histamin d\u00fcz kas ve kan damarlar\u0131n\u0131 etkileyerek d\u00fcz kas spazm\u0131na ve vazodilatasyona neden olur. Ayn\u0131 zamanda mukoza zar\u0131 ge\u00e7irgenli\u011fini art\u0131rarak burun ak\u0131nt\u0131s\u0131 ve g\u00f6z ya\u015farmas\u0131na da sebep olur. Antihistaminiklerin uygulanmas\u0131 bu etkilerin \u00e7o\u011funu bloke ederek onlar\u0131 d\u00fcnyada en yayg\u0131n kullan\u0131lan ila\u00e7lar haline getirir. Antihistaminikler, histamin resept\u00f6rlerinin birinde biyoaktif bir amin olan histaminin etkisini; ka\u015f\u0131nt\u0131, \u015fi\u015flik, k\u0131zar\u0131kl\u0131k, burun t\u0131kan\u0131kl\u0131\u011f\u0131, g\u00f6zlerde ya\u015flanma, \u00f6ks\u00fcr\u00fck, mide bulant\u0131s\u0131 ve ba\u015f d\u00f6nmesini engelleyerek etki eder. Antihistaminikler, sedatif (birinci nesil antihistaminikler) ve sedatif olmayan (ikinci nesil antihistaminikler) olarak s\u0131n\u0131fland\u0131r\u0131labilir. Aradaki fark, kan-beyin bariyerini ge\u00e7me yeteneklerinde yatmaktad\u0131r.<\/p>\n\n\n\n

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https:\/\/www.flickr.com\/photos\/sharynmorrow\/9308856\/in\/photolist-PHcw-25gvqHW-5E2B9x-5Dg5K2-58NXSh-QmSh-3jXXgw-4Lcsqo-6c5yi6-dVN3qZ-4utsN4-buZJpW-71oove-4JMZfz-2UzgGj-Re3wp9-5DknEw-5Dg4BR-5Dg5yM-7U1Fho-7vA69v-8vDgAK-5vm5bf-2jwxVhj-cn3dTJ-2jvr9gK-4MCv17-xW7MX-2jgcMMK-e6V5b5-2jvdpE6<\/figcaption><\/figure><\/div>\n\n\n\n

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Di\u011fer yandan kortikosteroidler dendi\u011finde akla ilk olarak Flonase gibi burun spreyleri gelir. Bu ila\u00e7lar histaminin etkileri ba\u015flamadan \u00f6nce inflamatuar h\u00fccrelerin migrasyonunu engeller.  Alerji ila\u00e7lar\u0131n\u0131n etkinli\u011fi \u00fczerine yap\u0131lan bir\u00e7ok \u00e7al\u0131\u015fman\u0131n meta-analizleri, burun i\u00e7i spreylerin antihistaminiklerden daha iyi sonu\u00e7 verdi\u011fini g\u00f6stermektedir. Bunun nedeni ise ilk etapta ger\u00e7ekle\u015fen inflamatuar s\u00fcreci engellemesidir. Dezavantajlar\u0131 ise etki s\u00fcresinin daha uzun olmas\u0131d\u0131r. Kortikosteroidler, k\u0131sa s\u00fcrelik rahatlama g\u00f6sterse de kesin sonucu 2-4 haftal\u0131k kullan\u0131mdan sonra g\u00f6sterirler. \u00c7\u00fcnk\u00fc ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizi d\u00fczenlemeye yard\u0131mc\u0131d\u0131rlar.<\/p>\n\n\n\n

Alerji ila\u00e7lar\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k sistemimizi etkileyebiliyorsa v\u00fccudumuzun verece\u011fi tepkiyi de de\u011fi\u015ftiremez mi?<\/strong><\/p>\n\n\n\n

Kemirgenlerle yap\u0131lan bir \u00e7al\u0131\u015fmada; antihistaminiklerin alerjenlere tolerans geli\u015fmesini engelleyebilece\u011fi g\u00f6sterilmi\u015ftir. Yap\u0131lan bu \u00e7al\u0131\u015fma yayg\u0131n olarak bilinen polen ve di\u011fer alerjenlere de\u011fil zehre dayan\u0131yordu. Fakat bu \u00e7al\u0131\u015fman\u0131n ilgin\u00e7 yan\u0131 insanlar de\u011fil kemirgenler \u00fczerinde yap\u0131lm\u0131\u015f olmas\u0131d\u0131r. Yani ayn\u0131 sorunun insanlarda da g\u00f6zlendi\u011fine dair hen\u00fcz yap\u0131lan bir \u00e7al\u0131\u015fma bulunmamaktad\u0131r.<\/p>\n\n\n\n

Antihistaminikler ve burun spreyleri gibi re\u00e7etesiz sat\u0131lan ila\u00e7lar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemimiz \u00fczerinde \u00f6nemli bir etkiye neden olmamas\u0131 bilim adamlar\u0131 taraf\u0131ndan da destek bulmaktad\u0131r. Alerjilerin k\u00f6t\u00fcle\u015fmesinde muhtemel su\u00e7lu olarak alerji ila\u00e7lar\u0131 g\u00f6r\u00fclmemelidir. \u0130\u00e7inde bulundu\u011fumuz mevsim, ge\u00e7irdi\u011fimiz s\u00fcre, ya\u015fad\u0131\u011f\u0131m\u0131z ortam\u0131n hijyen ko\u015fullar\u0131 ve ya\u015f \u00f6nemli bir kriter olabilmektedir. Mevsim ilerledik\u00e7e alerjik reaksiyonun ba\u015flamas\u0131 i\u00e7in gereken polen miktar\u0131 da daha az olmaktad\u0131r. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemi alerjenlere yan\u0131t vermeye haz\u0131r oldu\u011funda histamin reaksiyonlar\u0131 \u00e7ok k\u0131sa s\u00fcrede ba\u015flar. Bu y\u00fczden polen miktar\u0131 zirveye ula\u015fmadan \u00f6nce alerji ila\u00e7lar\u0131 kullan\u0131lmaya ba\u015flanmal\u0131 ve semptomlar\u0131n daha iyi y\u00f6netilebilmesi i\u00e7in bir alerji uzman\u0131ndan destek al\u0131nmal\u0131d\u0131r. Yap\u0131lacak alerji testleri etkenin saptanarak alerjene maruziyetin azalt\u0131lmas\u0131nda etkili olmaktad\u0131r.<\/p>\n\n\n\n

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KAYNAK\u00c7A:<\/strong><\/p>\n\n\n\n

  1. Johansen, P. vd. Clin. Tecr\u00fcbe. Alerji<\/em> DOI 10.1111\/ j.1365-2222.2007.0294.x (2008)<\/li>
  2. Ohashi, Y., Nakai, y. & Murata, K. Ann. Allergy. Ast\u0131m Immunol, <\/em>96, 600-605 (2006) (PubMed)<\/li><\/ol>\n\n\n\n

    3. M\u00fcller, U., Hari, Y. & Berchtold, E. J. Allergy Clin, Immunol<\/em>. 107, 81-86. (2001) (Makale PubMed)<\/p>\n\n\n\n

    4. Peper A. \u0130la\u00e7 dozu ve ila\u00e7 etkisi aras\u0131ndaki ili\u015fkinin y\u00f6nleri<\/a> . Doz Tepkisi<\/em> . 2009; 7 (2): 172-92. doi: 10.2203 \/ doz-yan\u0131t.08-019.Peper<\/p>\n\n\n\n

    5. https:\/\/www.oprah.com\/health\/whats-making-your-allergies-worse-how-to-find-allergy-relief<\/a><\/p>\n\n\n\n

    6. https:\/\/www.news-medical.net\/health\/Antihistamine-Side-Effects-When-to-Stop-Taking-Allergy-Medication.aspx<\/a><\/p>\n\n\n\n

    7. https:\/\/www.popsci.com\/allergy-medication-immune-system\/<\/a><\/p>\n\n\n\n

    8. https:\/\/istanbulalerjimerkezi.com.tr\/polen-alerjisi\/<\/p>\n","protected":false},"excerpt":{"rendered":"

    Bahar; kimimiz i\u00e7in ye\u015filin, do\u011fan\u0131n tazelenmesinin, ne\u015fenin, belki de yeni bir ya\u015f\u0131n (benim gibi :)) m\u00fcjdesidir. \u0130\u00e7ini k\u0131p\u0131r k\u0131p\u0131r eder<\/p>\n","protected":false},"author":387,"featured_media":10503,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"link","meta":[],"categories":[1,165],"tags":[2070,2074,2071,2068,2073,2075,2076,2080,2079,2069,2077],"acf":[],"views":1314,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/10500"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/387"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=10500"}],"version-history":[{"count":6,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/10500\/revisions"}],"predecessor-version":[{"id":10517,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/10500\/revisions\/10517"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/10503"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=10500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=10500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=10500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}