{"id":1111,"date":"2019-03-31T20:25:57","date_gmt":"2019-03-31T17:25:57","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=1111"},"modified":"2019-08-17T20:36:47","modified_gmt":"2019-08-17T17:36:47","slug":"diyabet-obezite-ve-asprosin","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/diyabet-obezite-ve-asprosin\/","title":{"rendered":"D\u0130YABET VE ASPROS\u0130N"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Diabetes Mellitus Nedir?<\/em><\/strong><\/p>\n\n\n\n

Diabetes Mellitus, Yunancada \u015fekerli idrar anlam\u0131na gelir. Diabetes mellitus, soya\u011fac\u0131 ve \u00e7evresel fakt\u00f6rlerle birlikte ortaya \u00e7\u0131kan ve kendini kan glikoz seviyesinin y\u00fckselmesi ile g\u00f6steren bir metabolik hastal\u0131kt\u0131r. Diyabetin temelini olu\u015fturan mekanizmalar ne kadar \u00e7abuk ortaya \u00e7\u0131karsa g\u00fcn\u00fcm\u00fczde ciddi bir halk sa\u011fl\u0131\u011f\u0131 sorunu olarak g\u00fcndemdeki yerini kaybedecektir. \u00c7\u00fcnk\u00fc diyabetin bu kadar \u00f6nemli g\u00f6r\u00fclmesi kalp hastal\u0131\u011f\u0131na, felce, k\u00f6rl\u00fc\u011fe, b\u00f6brek yetmezli\u011fine ve uzuv kayb\u0131na neden olan ve d\u00fcnyadaki her on bir ki\u015fiden birini etkileyen bir hastal\u0131k olmas\u0131d\u0131r.<\/p>\n\n\n\n

Asprosin Nedir?<\/em><\/strong><\/p>\n\n\n\n


\u0130ns\u00fclin direnci ile ili\u015fkili asprosin yeni ke\u015ffedilen bir peptid hormonudur. Asprosin, nanomolar seviyelerde dola\u015fan a\u00e7l\u0131k ile d\u00fczenlenir. \u0130ns\u00fclin direncine sahip hayvanlarda ve insanlarda Asprosin d\u00fczeylerinin artt\u0131\u011f\u0131 g\u00f6zlendi. Ayr\u0131ca, Glikoz miktarlar\u0131 d\u00fc\u015ft\u00fc\u011f\u00fcnde Asprosin seviyelerinin artt\u0131\u011f\u0131 saptand\u0131.<\/p>\n\n\n\n

Asprosin beyaz ya\u011f dokusundan salg\u0131lan\u0131r, karaci\u011fere al\u0131n\u0131r ve dola\u015f\u0131ma h\u0131zla glikoz sal\u0131n\u0131m\u0131na yol a\u00e7ar.\u00a0 <\/em><\/strong><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Bu bilgiler \u0131\u015f\u0131\u011f\u0131nda, diyabetin her Asprosin tipinde rol oynamas\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcr.<\/p>\n\n\n\n

Asprosin’in bu kadar \u00f6nemli olmas\u0131n\u0131n nedeni diyabet tedavisinde bir \u0131\u015f\u0131k olmas\u0131d\u0131r . \u00c7\u00fcnk\u00fc diyabetin sonu\u00e7lar\u0131 ger\u00e7ekten a\u011f\u0131r olabilir. Bunlardan \u00f6rnek vermek gerekirse: <\/p>\n\n\n\n

Bilindi\u011fi gibi, kan \u015fekeri kontrol alt\u0131na al\u0131namad\u0131\u011f\u0131nda, b\u00f6brek hasar\u0131 diyabetik ki\u015filerde mikrovask\u00fcler seviyede meydana gelir; Ba\u015fka bir deyi\u015fle, nefropati<\/em><\/strong> geli\u015fir ve bu ko\u015fullar son d\u00f6nem b\u00f6brek yetmezli\u011finin s\u0131k kar\u015f\u0131la\u015f\u0131lan nedenlerinden biridir. Ayn\u0131 \u015fekilde diyabetik retinopati<\/em><\/strong> buna ba\u011fl\u0131 olarak ortaya \u00e7\u0131kmaktad\u0131r. Hastal\u0131k ilerledik\u00e7e, anormal yeni vask\u00fclarizasyonlar retina y\u00fczeyinde meydana gelir ve k\u00f6rl\u00fc\u011fe neden olur.<\/p>\n\n\n\n

Kontrols\u00fcz bir \u015fekilde glukozun hepatik \u00fcretimi hiperglisemiye<\/em><\/strong> neden olur. Ancak, glikoz homeostaz\u0131, biyolojik sistemlerdeki glikoz fazlal\u0131\u011f\u0131 ve k\u0131tl\u0131\u011f\u0131 nedeniyle olu\u015facak hasarlar\u0131 ortadan kald\u0131rmak i\u00e7in \u00e7ok s\u0131k\u0131 kontrol alt\u0131ndad\u0131r. Ba\u015fka bir deyi\u015fle, Asprosin karaci\u011ferde glukoz olu\u015fumuna ne kadar sebep olursa olsun; pankreas beta h\u00fccrelerinde ins\u00fclin \u00fcretimini yaparak kan \u015fekeri seviyesini fizyolojik s\u0131n\u0131rlarda tutmaya \u00e7al\u0131\u015fmal\u0131d\u0131r<\/em><\/strong>. <\/em><\/strong>Ancak; ins\u00fclinin \u00fcretilmemesi veya \u00fcretilen ins\u00fclin direnci geli\u015fimi ve Asprosinin glukagonun a\u015f\u0131r\u0131 glukoz olu\u015fumuna veya glukoz sal\u0131n\u0131m\u0131n\u0131 artt\u0131rmas\u0131na katk\u0131s\u0131 patolojik durumlarda sorunlara neden olmaktad\u0131r.<\/p>\n\n\n\n

T\u00fcm bu bilgileri g\u00f6z \u00f6n\u00fcnde bulundurursak Asprosin bir glikojenik bir hormon oldu\u011fundan t\u00fcm diyabet tiplerinin<\/strong><\/em> etiyopatolojisinde, retinopati ve nefropati sendromlar\u0131nda<\/em><\/strong> yatan temel hormonlardan biri olabilir.<\/em><\/strong> K\u0131sa boyun<\/em><\/strong> da alt\u0131nda yatan nedenlerden biri olabilece\u011fi bile muhtemeldir. Zira Asprosinin a\u015f\u0131r\u0131 \u00fcretimi, a\u015f\u0131r\u0131 miktarda glikoz olu\u015fumuna neden oldu\u011fundan ve y\u00fcksek glikoz miktarlar\u0131 b\u00fcy\u00fcme hormonunu bask\u0131lad\u0131\u011f\u0131 i\u00e7in, k\u0131sa boylar ortaya \u00e7\u0131kabilmi\u015ftir. Gelecekte, bu \u00f6zelli\u011fi nedeniyle b\u00fcy\u00fcme hormonunun belirlenmesinde de kullan\u0131labilir.<\/p>\n\n\n\n

Gelecekte Anti-sprosin veya Asprosin yukar\u0131da belirtilen t\u00fcm hastal\u0131klar\u0131n tedavisinde terap\u00f6tik ajan olarak kullan\u0131labilecektir. \u0130ki y\u0131l i\u00e7inde insan \u00e7al\u0131\u015fmalar\u0131na da ba\u015flan\u0131lmas\u0131 d\u00fc\u015f\u00fcn\u00fclen bu hormon tip II diyabet, obezite ve metabolik sendrom gibi hastal\u0131klar\u0131n tedavilerinde umut vaat edici g\u00f6r\u00fcn\u00fcyor.<\/p>\n\n\n\n

KAYNAK\u00c7A<\/strong><\/p>\n\n\n\n

https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(16)30213-6<\/a><\/p>\n\n\n\n

https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30325247<\/a><\/p>\n\n\n\n

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5720914\/<\/a><\/p>\n\n\n\n

https:\/\/www.nature.com\/articles\/s41366-018-0248-1<\/a><\/p>\n\n\n\n

http:\/\/clinical-and-molecular-endocrinology.imedpub.com\/is-asprosin-a-real-actor-of-diabetes-etiopathology.php?aid=22680<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Diabetes Mellitus Nedir? Diabetes Mellitus, Yunancada \u015fekerli idrar anlam\u0131na gelir. Diabetes mellitus, soya\u011fac\u0131 ve \u00e7evresel fakt\u00f6rlerle birlikte ortaya \u00e7\u0131kan ve<\/p>\n","protected":false},"author":59,"featured_media":1116,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"acf":[],"views":4492,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/1111"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=1111"}],"version-history":[{"count":37,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/1111\/revisions"}],"predecessor-version":[{"id":2836,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/1111\/revisions\/2836"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/1116"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=1111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=1111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=1111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}