{"id":1237,"date":"2019-04-13T23:40:38","date_gmt":"2019-04-13T20:40:38","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=1237"},"modified":"2019-04-28T21:27:12","modified_gmt":"2019-04-28T18:27:12","slug":"vitiligo-ve-genetik","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/vitiligo-ve-genetik\/","title":{"rendered":"V\u0130T\u0130L\u0130GO VE GENET\u0130K"},"content":{"rendered":"\n

Yaz\u0131y\u0131 okumaya ba\u015flamadan \u00f6nce ciltteki depigmentasyonlu alanlar\u0131 dikkatle incelemenizi tavsiye ederim \ud83d\ude42<\/p>\n\n\n\n

\"\"
2009 y\u0131l\u0131nda hayat\u0131n\u0131 kaybeden Michael Jackson’\u0131n ger\u00e7ekte vitiligo hastas\u0131 oldu\u011fu otopsi raporunda kan\u0131tland\u0131. Belki de o d\u00fcnyan\u0131n en \u00fcnl\u00fc vitiligo hastas\u0131yd\u0131.<\/em>


<\/figcaption><\/figure>\n\n\n\n

V\u0130T\u0130L\u0130GO NED\u0130R?<\/strong><\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

Vitiligo, cildin \u00fczerinde olu\u015fan beyaz yamalar ile karakterize edilmi\u015f, \u00e7ok fakt\u00f6rl\u00fc otoimm\u00fcn bir bozukluktur. Vitiligo, cildin pigmentasyonunu sa\u011flayan melanositlerin hasar g\u00f6rmesi veya kaybolmas\u0131ndan kaynaklan\u0131r. Nispeten yayg\u0131n olarak g\u00f6r\u00fclen bu pigmentasyon bozuklu\u011fu bazen sa\u00e7\u0131n ve v\u00fccut k\u0131llar\u0131n\u0131n da d\u00f6k\u00fclmesine sebebiyet verebilir.<\/p>\n\n\n\n


Depigmentasyon genellikle boyunda, uzuvlarda,a\u011f\u0131z kenar\u0131 ve genital b\u00f6lgede g\u00f6zlemlenir.Ayriyeten, dudak gibi mukus membranlar\u0131nda da pigment kayb\u0131 ya\u015fanabilir.<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n


Vitiligo, genellikle hayat boyunca ilerlemeye meyilli bir bozukluktur. Bilim insanlar\u0131 vitiligonun iki formu oldu\u011funu belirtiyorlar.Bunlar:<\/p>\n\n\n\n

  1. Segmental Vitiligo: V\u00fccudun sadece bir segmentini veya taraf\u0131n\u0131 etkileyen bu form, sadece birka\u00e7 y\u0131l boyunca ilerler. Erken ya\u015flarda ba\u015flayan bu formda sa\u00e7,kirpik veya ka\u015f kayb\u0131 genellikle g\u00f6r\u00fclmez.<\/li>
  2. Segmental Olmayan Vitiligo: Daha s\u0131k kar\u015f\u0131la\u015f\u0131lan bu formda ise v\u00fccudun her iki taraf\u0131 da etkilenir.Genellikle ellerde, ayaklarda veya y\u00fczlerde k\u0131sa s\u00fcreli bir renk de\u011fi\u015fikli\u011fi patlamas\u0131yla ba\u015flar.Etkilenen b\u00f6lgeler, ki\u015finin ya\u015fam\u0131 boyunca meydana gelen yeni pigment kayb\u0131 \u00e7evrimleriyle geni\u015flemeye devam eder. <\/li><\/ol>\n\n\n\n

    Vitiligo genellikle yirmili ya\u015flar\u0131n ortas\u0131nda ortaya \u00e7\u0131kar. Vitiligo fiziksel sa\u011fl\u0131\u011f\u0131 etkilemez etkilemez ama cilt kanseri riskini ve iris enflamasyonu riskini artt\u0131r\u0131r. Bununla beraber, 2011 y\u0131l\u0131nda Pubmed’de yay\u0131nlanan makalede bu hastal\u0131\u011f\u0131n en y\u0131k\u0131c\u0131 psikolojik bozuklardan bir\u0130 oldu\u011fu ve hastal\u0131\u011f\u0131n psikolojik etkilerinin, cilt bozukluklu\u011funun toplumsal alg\u0131s\u0131ndan \u00e7ok etkilendi\u011fi belirtilmi\u015ftir. <\/p>\n\n\n\n

    V\u0130T\u0130L\u0130GONUN KALITIM VE GENET\u0130K \u0130LE \u0130L\u0130\u015eK\u0130S\u0130<\/strong><\/p>\n\n\n\n

    Vitiligoyu bazen aile i\u00e7inde birden fazla bireyde oldu\u011funu g\u00f6r\u00fcr\u00fcz. Genetik \u015femas\u0131 kompleks olan bu bozuklukta \u00e7oklu nedensel fakt\u00f6rler \u00f6n plandad\u0131r. Fakat buna ra\u011fmen, bir ailenin i\u00e7inde birden fazla vitiligolu birey g\u00f6rmemiz imkans\u0131z de\u011fildir.Vitiligo hastalar\u0131n\u0131n yakla\u015f\u0131k% 25-% 50’sinin vitiligolu bir akrabas\u0131 vard\u0131r ve yakla\u015f\u0131k % 6’s\u0131n\u0131n vitiligolu karde\u015fleri vard\u0131r. <\/p>\n\n\n\n

    Vitiligo, epidemiyolojik olarak, \u00e7oklu otoimm\u00fcn hastal\u0131kla ili\u015fkilidir. Bu hastlal\u0131klar\u0131n aras\u0131nda, otoimm\u00fcn tiroit hastal\u0131\u011f\u0131, pernisy\u00f6z anemi, romatid artrit, tip-1 diyabet, Addison hastal\u0131\u011f\u0131 ve lupus hastal\u0131\u011f\u0131 vard\u0131r. <\/p>\n\n\n\n

    Ara\u015ft\u0131rmac\u0131lar, vitiligo ile geneti\u011fin aras\u0131ndaki ili\u015fkiye dair bir s\u00fcr\u00fc \u00e7al\u0131\u015fmalar yapt\u0131lar. Bu \u00e7al\u0131\u015fmalar\u0131n sonucunda, baz\u0131 genetik fakt\u00f6rlerin vitiligo ile ili\u015fkili oldu\u011funu ortaya \u00e7\u0131kard\u0131lar.Fakat genetik fakt\u00f6rlerin \u00e7evre ko\u015fullar\u0131yla olan ili\u015fkisinin bu bozuklu\u011fun olu\u015fmunda \u00f6nemli bir yerinin oldu\u011fu bilinen bir ger\u00e7ek.<\/p>\n\n\n\n

    \"\"<\/figure><\/div>\n\n\n\n

    Vitiligo i\u00e7in yap\u0131lan \u00e7al\u0131\u015fmalarda, “Melanin Biyosentezi, Oksidatif Stres, Otoimm\u00fcniteyi D\u00fczenleyen Genler” \u00fczerinde \u00f6zellikle durulmu\u015ftur. Vitiligolu bireyler \u00fczerinde ger\u00e7ekle\u015ftirilen, geni\u015f kapsaml\u0131 genom \u00e7al\u0131\u015fmalar\u0131n\u0131n sonucunda vitiligonun duyarl\u0131l\u0131k lokuslar\u0131yla ili\u015fkili oldu\u011fu yani genetik oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r.<\/p>\n\n\n\n

    Vitiligo hastal\u0131\u011f\u0131, eksik penetrasyon, \u00e7oklu duyarl\u0131l\u0131k lokuslar\u0131 ve genetik heterojenize ile karakterizedir. \u015eunu da belirtmemiz gerekirse, vitiligo geni diye bir gen yoktur. Vitiligonun MHC ve TYR adl\u0131 iki genin farkl\u0131 farkl\u0131 versiyonlar\u0131ndan t\u00fcredi\u011fi d\u00fc\u015f\u00fcn\u00fcl\u00fcr.<\/p>\n\n\n\n

    V\u0130T\u0130L\u0130GONUN TEDAV\u0130S\u0130 <\/strong><\/p>\n\n\n\n

    Amerikan Dermatoloji Akademisi, vitiligoyu t\u0131bbi \u00f6zene ihtiya\u00e7 duyan kozmetik bir problem olarak tan\u0131mlar. Vitiligoyu tamamen iyile\u015ftirmek \u015fu an i\u00e7in pek m\u00fcmk\u00fcn de\u011fil. Ama \u00e7e\u015fitli y\u00f6ntemlerle kozmetik kayg\u0131lar\u0131 gidermek pek ala m\u00fcmk\u00fcn. Y\u00f6ntemleri s\u0131ralayacak olursak;<\/p>\n\n\n\n

    1. G\u00fcne\u015f kremi kullanmak<\/li>
    2. UVB veya UVA ile fototerapi<\/li>
    3. Cildi kamufle etmek<\/li>
    4. Depigmente ettirmek<\/li>
    5. Kortikosteroid<\/li>
    6. Ba\u011f\u0131\u015f\u0131kl\u0131k Sistemini etkileyen ila\u00e7lar<\/li>
    7. Deri grefti<\/li>
    8. D\u00f6vme yapt\u0131rmak<\/li><\/ol>\n\n\n\n
      \"\"<\/figure><\/div>\n\n\n\n

      V\u0130T\u0130L\u0130GONUN GELECEKTEK\u0130 TEDAV\u0130S\u0130<\/strong><\/p>\n\n\n\n

      \"\"<\/figure><\/div>\n\n\n\n

      Vitiligo i\u00e7in alternatif tedavi y\u00f6ntemi aray\u0131\u015f\u0131 s\u00fcrmektedir ve bilim insanlar\u0131 Psod\u00f6katalaz ve sentetik melanosit stim\u00fcle edici hormondan \u00fcmitli g\u00f6r\u00fcn\u00fcyor.<\/p>\n\n\n\n

      <\/p>\n\n\n\n

      <\/p>\n\n\n\n

      <\/p>\n\n\n\n

      <\/p>\n\n\n\n

      Kaynaklar<\/p>\n\n\n\n

      1. https:\/\/ghr.nlm.nih.gov\/condition\/vitiligo<\/li>
      2. http:\/\/turkdermatoloji.org.tr\/public\/media\/hasta_bilgilendirme\/vitiligo.pdf<\/li>
      3. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022202X1535572X<\/li>
      4. https:\/\/europepmc.org\/abstract\/med\/6192645<\/li>
      5. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896841105001368<\/li>
      6. https:\/\/rarediseases.info.nih.gov\/diseases\/10751\/vitiligo<\/li>
      7. https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1600-0749.2007.00384.x<\/li>
      8. https:\/\/genetics.thetech.org\/ask\/ask369<\/li>
      9. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3521835\/<\/li>
      10. https:\/\/www.sciencedaily.com\/releases\/2016\/10\/161010135929.htm<\/li>
      11. https:\/\/www.innerbody.com\/diseases-conditions\/vitiligo<\/li>
      12. https:\/\/www.mayoclinic.org\/diseases-conditions\/vitiligo\/symptoms-causes\/syc-20355912<\/li>
      13. https:\/\/www.medicalnewstoday.com\/articles\/245081.php<\/li>
      14. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5362127\/<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

        Yaz\u0131y\u0131 okumaya ba\u015flamadan \u00f6nce ciltteki depigmentasyonlu alanlar\u0131 dikkatle incelemenizi tavsiye ederim \ud83d\ude42 V\u0130T\u0130L\u0130GO NED\u0130R? Vitiligo, cildin \u00fczerinde olu\u015fan beyaz yamalar<\/p>\n","protected":false},"author":52,"featured_media":1247,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[140,148,138,141,145,146,149,115,142,147,150,139,137,62,143,144,84,136,151],"acf":[],"views":9995,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/1237"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/52"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=1237"}],"version-history":[{"count":4,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/1237\/revisions"}],"predecessor-version":[{"id":1250,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/1237\/revisions\/1250"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/1247"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=1237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=1237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=1237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}