{"id":13101,"date":"2022-12-01T22:33:40","date_gmt":"2022-12-01T19:33:40","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=13101"},"modified":"2023-01-01T20:59:22","modified_gmt":"2023-01-01T17:59:22","slug":"ayni-formul-farkli-3d-gorunum","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/ayni-formul-farkli-3d-gorunum\/","title":{"rendered":"Ayn\u0131 form\u00fcl farkl\u0131 3D g\u00f6r\u00fcn\u00fcm"},"content":{"rendered":"\n

Bir ilac\u0131n ya da bir kimyasal bile\u015fi\u011fin uzaydaki duru\u015flar\u0131na g\u00f6re farkl\u0131l\u0131k g\u00f6sterdi\u011fini biliyor muydunuz? Bunu baz\u0131 bile\u015fiklerin k\u00f6t\u00fc bir ikizinin oldu\u011fu olarak da tan\u0131mlayabiliriz.
\u00c7\u00fcnk\u00fc bu bile\u015fikler tamamen ayn\u0131 form\u00fcle sahip olsalar da 3D g\u00f6r\u00fcn\u00fcmlerinin farkl\u0131 olmas\u0131ndan dolay\u0131 baya da bir farkl\u0131l\u0131k g\u00f6sterebiliyorlar.<\/p>\n\n\n\n

Bu yap\u0131lara \u00f6rnek verecek olursak \u00f6ncelikle sonucu korkun\u00e7 bir hikayeye ba\u011flanan bir ila\u00e7la ba\u015flayal\u0131m ”talidomid felaketi”. Talidomid asl\u0131nda bir sabah bulant\u0131 ilac\u0131 olmas\u0131 sebebiyle bir\u00e7ok hamile kad\u0131na yayg\u0131n olarak 1957 ve 1962 y\u0131llar\u0131nda re\u00e7ete edildi. Bununla birlikte, hamileli\u011fin ilk \u00fc\u00e7 ay\u0131nda al\u0131nd\u0131\u011f\u0131nda, Thalidomid fet\u00fcs\u00fcn d\u00fczg\u00fcn b\u00fcy\u00fcmesini engelledi ve sonu\u00e7 olarak, d\u00fcnya \u00e7ap\u0131nda binlerce \u00e7ocu\u011fun ciddi do\u011fum kusurlar\u0131 ile do\u011fmas\u0131na sebep oldu. \u00c7\u00fcnk\u00fc asl\u0131nda talidomid kiral bir molek\u00fcld\u00fc ve bir formu yat\u0131\u015ft\u0131r\u0131c\u0131 bir etkiye sebep olsa da bir di\u011fer formu anormal fiziksel geli\u015fime sebep olmaktayd\u0131.<\/p>\n\n\n\n

Talidomidin 2 formu:<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

R-talidomid enantiyomeri resept\u00f6re ba\u011fland\u0131\u011f\u0131nda ilac\u0131n ama\u00e7lanan etkileri meydana gelirken S-talidomid enantiyomeri resept\u00f6re ba\u011fland\u0131\u011f\u0131nda etkileri teratojeniktir, fet\u00fcste yeni kan damar\u0131 b\u00fcy\u00fcmesini engeller ve dolay\u0131s\u0131yla do\u011fum kusurlar\u0131na neden olur.
Fakat sonras\u0131nda bu sorun daha da karma\u015f\u0131kla\u015f\u0131r. \u00c7\u00fcnk\u00fc insan karaci\u011ferinin R-talidomidi S-talidomide d\u00f6n\u00fc\u015ft\u00fcrebilen bir enzim i\u00e7erdi\u011fi bulunur ve bu nedenle enantiyomerik olarak saf R-talidomidin uygulanmas\u0131 bile her bir enentiyomerin rasemik (50\/50) kar\u0131\u015f\u0131m\u0131yla sonu\u00e7lan\u0131r. Bu, S-enantiyomerinin, ba\u015flang\u0131\u00e7ta al\u0131nm\u0131\u015f olsun ya da olmas\u0131n v\u00fccutta bulunaca\u011f\u0131 ve dolay\u0131s\u0131yla yine de olumsuz etkilere neden olabilece\u011fi anlam\u0131na gelir.<\/p>\n\n\n\n

Yazar: Senanur G\u00fclce
Edit\u00f6rler: \u0130dil Alt\u0131nta\u015f, Hilal T\u00fcrkan<\/p>\n\n\n\n

<\/p>\n\n\n\n

Nature’s mirror: The code for chirality: https:\/\/www.sciencedaily.com\/releases\/2016\/02\/160208124237.htm<\/p>\n\n\n\n

The Thalidomide Disaster teaches us an important lesson about optical isomerism in Pharmacology: https:\/\/www.thescienceworkspace.com\/blog\/the-thalidomide-disaster-teaches-us-an-important-lesson-about-optical-isomerism-in-pharmacology<\/p>\n\n\n\n

Many drugs have mirror image chemical structures \u2013 while one may be helpful, the other may be harmful: https:\/\/theconversation.com\/many-drugs-have-mirror-image-chemical-structures-while-one-may-be-helpful-the-other-may-be-harmful-186975<\/p>\n","protected":false},"excerpt":{"rendered":"

Bir ilac\u0131n ya da bir kimyasal bile\u015fi\u011fin uzaydaki duru\u015flar\u0131na g\u00f6re farkl\u0131l\u0131k g\u00f6sterdi\u011fini biliyor muydunuz? Bunu baz\u0131 bile\u015fiklerin k\u00f6t\u00fc bir ikizinin<\/p>\n","protected":false},"author":1151,"featured_media":13105,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,25],"tags":[73,76,66],"acf":[],"views":270,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/13101"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/1151"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=13101"}],"version-history":[{"count":2,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/13101\/revisions"}],"predecessor-version":[{"id":13341,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/13101\/revisions\/13341"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/13105"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=13101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=13101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=13101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}