Stresli ve endi\u015feli oldu\u011funuzda kalp at\u0131\u015flar\u0131m\u0131z\u0131n artmas\u0131 normaldir. Peki, kalbimiz korktu\u011fumuz i\u00e7in mi h\u0131zl\u0131 at\u0131yor? Yoksa h\u0131zlanan kalbimiz endi\u015femize katk\u0131da m\u0131 bulunuyor? Farelerde yap\u0131lan yeni bir \u00e7al\u0131\u015fma, her ikisinin de do\u011fru olabilece\u011fini kan\u0131tl\u0131yor.
Bilim adamlar\u0131, farelerin kalp at\u0131\u015f h\u0131zlar\u0131n\u0131 yapay olarak art\u0131rarak kayg\u0131 benzeri davran\u0131\u015flar\u0131nda artma g\u00f6zlemlediler. 9 Mart Nature’da yay\u0131nlanan bir \u00e7al\u0131\u015fma, y\u00fcksek riskli durumlarda h\u0131zl\u0131 bir kalbin beyninize etki edebilece\u011fini ve kayg\u0131y\u0131 art\u0131rabilece\u011fini de g\u00f6steriyor.
Stanford \u00dcniversitesi’nden bir sinirbilimci olan Karl Deisseroth, beden duyumlar\u0131n\u0131n beyindeki duygulara katk\u0131da bulunabilece\u011fi fikrinin en az\u0131ndan psikolojinin kurucular\u0131ndan biri olan William James’e kadar uzand\u0131\u011f\u0131n\u0131 s\u00f6yl\u00fcyor. James’in 1890 tarihli The Principles of Psychology adl\u0131 kitab\u0131nda, duygular\u0131n v\u00fccudun deneyimlediklerini takip etti\u011fine inand\u0131\u011f\u0131n\u0131 s\u00f6yler. James bu fikri, “A\u011flad\u0131\u011f\u0131m\u0131z i\u00e7in \u00fcz\u00fcl\u00fcyoruz, vurdu\u011fumuz i\u00e7in k\u0131z\u0131yoruz, titredi\u011fimiz i\u00e7in korkuyoruz” \u015feklinde bizlere aktard\u0131.
Beyin kesinlikle dahili v\u00fccut sinyallerini alg\u0131layabilir, bu da interosepsiyon ad\u0131 verilen bir olgu olarak a\u00e7\u0131klan\u0131r. Ancak Bordeaux’daki Frans\u0131z Ulusal Sa\u011fl\u0131k ve T\u0131bbi Ara\u015ft\u0131rma Enstit\u00fcs\u00fc’nden sinirbilimci Anna Beyeler, bu hislerin – h\u0131zl\u0131 atan bir kalp gibi – duyguya katk\u0131da bulunup bulunmad\u0131\u011f\u0131n\u0131 kan\u0131tlaman\u0131n zor oldu\u011funu s\u00f6yl\u00fcyor.
Deisseroth, \u0131\u015f\u0131k patlamalar\u0131na yan\u0131t vermek \u00fczere belirli h\u00fccrelerin genlerini de\u011fi\u015ftirmek i\u00e7in vir\u00fcsleri kullanan bir teknik olan optogeneti\u011fi geli\u015ftiren bilim insanlar\u0131ndan biridir. Yeni \u00e7al\u0131\u015fmada, Deisseroth ve meslekta\u015flar\u0131, farenin kalp at\u0131\u015f h\u0131z\u0131n\u0131 de\u011fi\u015ftirmek i\u00e7in bir farenin geneti\u011fiyle oynanm\u0131\u015f kalbinin \u00fczerindeki k\u00fc\u00e7\u00fck bir yele\u011fe tak\u0131lan bir \u0131\u015f\u0131k kulland\u0131lar. I\u015f\u0131k s\u00f6nd\u00fc\u011f\u00fcnde, bir farenin kalbi dakikada yakla\u015f\u0131k 600 kere att\u0131. Fakat ekip dakikada 900 vuru\u015fla yan\u0131p s\u00f6nen bir \u0131\u015f\u0131\u011f\u0131 yakt\u0131\u011f\u0131nda, farenin kalp at\u0131\u015f\u0131 da ayn\u0131 \u015feyi yapt\u0131. Deisseroth, bu durumu “Bu, bir farenin stres veya korku an\u0131nda kar\u015f\u0131la\u015fabilece\u011fi g\u00fczel, makul bir h\u0131zlanma” \u015feklinde ifade ediyor.
Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca artan kalp at\u0131\u015f h\u0131z\u0131n\u0131 i\u015fleyebilecek alanlar\u0131 bulmak i\u00e7in hayvanlar\u0131n beyinlerini tarad\u0131lar. Deisseroth, en b\u00fcy\u00fck sinyallerden birinin arka insuladan geldi\u011fini g\u00f6rd\u00fcler. Bunu ” \u0130nteroseptif devrelerle y\u00fcksek oranda ba\u011flant\u0131l\u0131 olmas\u0131ndan dolay\u0131 insuladan bu sinyallerin gelmesi ilgin\u00e7ti.” diye yorumluyorlar. Ayr\u0131ca bilim insanlar\u0131 “Bu sinyali g\u00f6rd\u00fc\u011f\u00fcm\u00fczde, bizim ilgimiz kesinlikle artt\u0131.” diye de ekliyor.
Daha fazla optogenetik kullanan ekip, posterior insulada aktiviteyi azaltt\u0131klar\u0131nda farelerin kayg\u0131 benzeri davran\u0131\u015flar\u0131n\u0131 azaltt\u0131\u011f\u0131n\u0131 g\u00f6zlemlediler.
Beyeler, kalp ve beyin aras\u0131ndaki ba\u011flant\u0131y\u0131 anlaman\u0131n, sonunda doktorlar\u0131n panik ve kayg\u0131y\u0131 nas\u0131l tedavi etti\u011fini etkileyebilece\u011fini s\u00f6yl\u00fcyor. Ancak laboratuvar ve klinik aras\u0131ndaki yolun, kalpten beyne giden yoldan \u00e7ok daha dolamba\u00e7l\u0131 oldu\u011funu da ekliyor.<\/p>\n\n\n\n
Yazar: Senanur G\u00fclce<\/p>\n\n\n\n
Edit\u00f6rler: \u0130dil Alt\u0131nta\u015f, Hilal T\u00fcrkan<\/p>\n\n\n\n
https:\/\/www.sciencenews.org\/article\/mice-anxiety-brain-heart-emotion <\/p>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
Stresli ve endi\u015feli oldu\u011funuzda kalp at\u0131\u015flar\u0131m\u0131z\u0131n artmas\u0131 normaldir. Peki, kalbimiz korktu\u011fumuz i\u00e7in mi h\u0131zl\u0131 at\u0131yor? Yoksa h\u0131zlanan kalbimiz endi\u015femize katk\u0131da<\/p>\n","protected":false},"author":1151,"featured_media":13908,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,25],"tags":[73,76],"acf":[],"views":213,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/13907"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/1151"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=13907"}],"version-history":[{"count":1,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/13907\/revisions"}],"predecessor-version":[{"id":13909,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/13907\/revisions\/13909"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/13908"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=13907"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=13907"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=13907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}