{"id":14061,"date":"2023-08-27T20:26:55","date_gmt":"2023-08-27T17:26:55","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=14061"},"modified":"2023-08-27T20:26:58","modified_gmt":"2023-08-27T17:26:58","slug":"klotho-ve-yasli-maymunlardaki-bilissel-basariya-etkisi","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/klotho-ve-yasli-maymunlardaki-bilissel-basariya-etkisi\/","title":{"rendered":"\u00a0Klotho ve Ya\u015fl\u0131 Maymunlardaki Bili\u015fsel Ba\u015far\u0131ya Etkisi"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" src=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/natyreeeeeeeeeee-1024x1024.png\" alt=\"\" class=\"wp-image-14065\" width=\"501\" height=\"501\" srcset=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/natyreeeeeeeeeee-1024x1024.png 1024w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/natyreeeeeeeeeee-150x150.png 150w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/natyreeeeeeeeeee-1536x1536.png 1536w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/natyreeeeeeeeeee-2048x2048.png 2048w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/natyreeeeeeeeeee-768x768.png 768w\" sizes=\"(max-width: 501px) 100vw, 501px\" \/><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>San Fransisco- Ya\u015fam\u0131 uzat\u0131c\u0131 etkisi oldu\u011fu \u00f6nceden g\u00f6sterilmi\u015f olan Klotho proteininin tek seferlik subkutan enjeksiyonunun, Rhesus maymunlar\u0131nda bili\u015fsel yetene\u011fi en az 2 hafta s\u00fcreyle artt\u0131rd\u0131\u011f\u0131 g\u00f6zlenmi\u015ftir. Nature Aging dergisinde \u00f6ne \u00e7\u0131kan bu sonu\u00e7lar klinik \u00e7al\u0131\u015fmalar i\u00e7in temel olu\u015fturmaktayd\u0131.<\/p>\n\n\n\n<p>Japon bir ara\u015ft\u0131rmac\u0131, 1997 y\u0131l\u0131nda tuza duyarl\u0131 hipertonisi olan transgenik fareler yeti\u015ftirdi\u011fi esnada tesad\u00fcfen Klotho genine denk geldi. Hayvanlardan biri premat\u00fcre olup; bu hayvanda arterioskleroz, osteoporoz, ya\u015fa ba\u011fl\u0131 cilt de\u011fi\u015fiklikleri ve ektopik ya\u015flanma g\u00f6zlendi. Ya\u015fam beklentisi \u00e7ok k\u0131sayd\u0131.<\/p>\n\n\n\n<p>Tokyo\u2019da Devlet Enstit\u00fcs\u00fcnde n\u00f6robilimci olan Makato Kuro-o ve \u00e7al\u0131\u015fan\u0131 bir gendeki kusurlu de\u011fi\u015fikliklerin sebebini ortaya \u00e7\u0131karm\u0131\u015flard\u0131. Bu gene daha sonradan Klotho ismi verilmi\u015fti. Klotho ismi, Yunan mitolojisinde insanlar\u0131n ya\u015fam s\u00fcresini belirleyen ipli\u011fi d\u00f6nd\u00fcren kader tanr\u0131\u00e7alar\u0131ndan birinden esinlenilmi\u015ftir. Ara\u015ft\u0131rmac\u0131, Klotho art\u0131\u015f\u0131n\u0131n farelerdeki ya\u015fam s\u00fcresini %10 ile %20 oran\u0131nda artt\u0131rd\u0131\u011f\u0131n\u0131 da g\u00f6zlemi\u015ftir.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" src=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/2314Asset-5-1-1024x509.png\" alt=\"\" class=\"wp-image-14066\" width=\"499\" height=\"469\" \/><figcaption><strong><mark class=\"has-inline-color has-vivid-purple-color\">Klotho miktar\u0131n\u0131n ya\u015fam s\u00fcresine etkisi<\/mark><\/strong><\/figcaption><\/figure><\/div>\n\n\n<p>Gen \u00fcr\u00fcn\u00fc Klotho ile yap\u0131lan tedavilerde de benzer etkiler g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Normalde h\u00fccre membran\u0131n\u0131n bir par\u00e7as\u0131d\u0131r lakin kana protein olarak da verilmektedir. V\u00fccuttaki fonksiyonlar\u0131 tam olarak bilinmemekle beraber kan\u0131tlanm\u0131\u015f baz\u0131 etkileri bulunmaktad\u0131r. \u0130ns\u00fclindeki, fibroblastik b\u00fcy\u00fcme fakt\u00f6r\u00fcndeki, N-Metil-D-Aspartat resept\u00f6r\u00fcndeki etkileri bunlar aras\u0131ndad\u0131r.<\/p>\n\n\n\n<p>Klotho proteini,farelerde \u015fa\u015f\u0131rt\u0131c\u0131 bir \u015fekilde n\u00f6rodejeneratif hastal\u0131klara olan dayan\u0131kl\u0131l\u0131\u011f\u0131 artt\u0131rm\u0131\u015ft\u0131r \u00e7\u00fcnk\u00fc bu protein kan-beyin bariyerini a\u015famamaktad\u0131r. Buna ra\u011fmen yap\u0131lan \u00e7al\u0131\u015fmalarda Klotho proteininin, farelerin n\u00f6ronlar\u0131ndaki neoplazmay\u0131 (yeni doku olu\u015fumu) artt\u0131rd\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Bu artm\u0131\u015f n\u00f6ronal plastisite kemirgenlerdeki bili\u015fsel yetene\u011fin iyi y\u00f6nde etkilendi\u011fini ortaya koymu\u015ftur.<\/p>\n\n\n\n<p>Klotho proteininin \u00e7\u00f6z\u00fcnebilen formu, alfa-klotho olarak da isimlendirilir ve bu form insanlar taraf\u0131ndan da \u00fcretilebilmi\u015ftir. Alfa-Klotho\u2019nun en y\u00fcksek konsantrasyonu kordon kan\u0131nda bulunmu\u015ftur. Ya\u015fland\u0131k\u00e7a kandaki konsantrasyonu da azalmaktad\u0131r.<\/p>\n\n\n\n<p>\u0130nsanlarda beyindeki Tau proteini ve Beta amiloid art\u0131klar\u0131n\u0131n azalmas\u0131yla, Klotho\u2019nun gen varyasyonlar\u0131n\u0131n kesinlikle ili\u015fkili oldu\u011fu g\u00f6sterilmi\u015ftir. Gen ta\u015f\u0131y\u0131c\u0131lar\u0131n\u0131n ya\u015fl\u0131l\u0131kta Alzheimer hastal\u0131\u011f\u0131na yakalanma riskini azaltt\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n\n\n\n<p>Kaliforniya \u00dcniversitesi\u2019nde Dena Dubal\u2019\u0131n ekibi Klotho\u2019nun terap\u00f6tik potansiyelini ke\u015ffettiler. Ara\u015ft\u0131rmac\u0131 Klotho proteininin Makak (bir maymun t\u00fcr\u00fc) versiyonunu \u00fcretti, ayr\u0131ca farelerdeki proteini ayr\u0131\u015ft\u0131rd\u0131 ve aminoasit dizisinin insanlardaki Klotho ile %96 oran\u0131nda benzer oldu\u011funu tespit etti.<\/p>\n\n\n\n<p>Farelerdeki ilk g\u00fcvenlik testinden sonra makaklardaki etkiler de ara\u015ft\u0131r\u0131ld\u0131. Rhesus maymunlar\u0131nda (makaklar\u0131n alt t\u00fcr\u00fc) 22 ya\u015f, insanlardaki 65 ya\u015fa denktir.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" src=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2023\/08\/rhesus-maymunu-1024x1024.jpg\" alt=\"\" class=\"wp-image-14064\" width=\"474\" height=\"451\" \/><figcaption><strong>Rhesus Maymunu<\/strong><\/figcaption><\/figure><\/div>\n\n\n<p>Standart bir testte, toplam 18 hayvan\u0131n kafesteki dokuz gizli delikten hangisinde yiyecek bulabileceklerini hat\u0131rlamas\u0131 gerekiyordu.<\/p>\n\n\n\n<p>10 \u00b5g\/kg subkutan Klotho enjeksiyonundan 4 saat sonra plasebo enjeksiyonu yap\u0131lan kar\u015f\u0131la\u015ft\u0131rma grubundan daha iyi sonu\u00e7 elde ettikleri g\u00f6zlenmi\u015ftir. Etkisi yakla\u015f\u0131k 2 hafta s\u00fcrm\u00fc\u015ft\u00fcr.<\/p>\n\n\n\n<p>Etki s\u00fcresi Klotho\u2019nun yar\u0131 \u00f6mr\u00fcnden dolay\u0131 ya\u015fl\u0131 makaklarda yakla\u015f\u0131k 29,5 saatte sona ermi\u015ftir. Burada Klotho maddesinin bu etkileri kendisinin de\u011fil aksine sinyal maddeleri arac\u0131l\u0131\u011f\u0131yla ger\u00e7ekle\u015ftirdi\u011fi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Bu durum kan-beyin bariyerini a\u015famayan Klotho maddesinin beyindeki etkilerini de a\u00e7\u0131klamaktad\u0131r.<\/p>\n\n\n\n<p>\u015ea\u015f\u0131rt\u0131c\u0131 bir \u015fekilde daha y\u00fcksek dozlarda (20 \u00b5g\/kg&nbsp;ile 30 \u00b5g\/kg&nbsp;aras\u0131) yap\u0131lan tedavi denemelerinin etkisiz oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Haf\u0131za testi sonu\u00e7lar\u0131 plasebo grubundan daha iyi de\u011fildi ve bunun sebebi tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p>Dubal, insanlarda d\u00fc\u015f\u00fck dozlar\u0131n ya\u015fl\u0131l\u0131kta bili\u015fsel yetenekleri geli\u015ftirmek i\u00e7in terap\u00f6tik bir pencere a\u00e7abilece\u011fi sonucuna varm\u0131\u015ft\u0131r. Bununla birlikte, klinik ara\u015ft\u0131rmalar i\u00e7in herhangi bir plan yok gibi g\u00f6r\u00fcnmektedir.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Okudu\u011funuz i\u00e7in te\u015fekk\u00fcrler..<\/p>\n\n\n\n<p>KAYNAK\u00c7A<\/p>\n\n\n\n<p><a href=\"https:\/\/www.aerzteblatt.de\/\">https:\/\/www.aerzteblatt.de\/<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>San Fransisco- Ya\u015fam\u0131 uzat\u0131c\u0131 etkisi oldu\u011fu \u00f6nceden g\u00f6sterilmi\u015f olan Klotho proteininin tek seferlik subkutan enjeksiyonunun, Rhesus maymunlar\u0131nda bili\u015fsel yetene\u011fi en<\/p>\n","protected":false},"author":1238,"featured_media":14068,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2176,1,2173,25],"tags":[2434,543,115,1218],"acf":[],"views":236,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/14061"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/1238"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=14061"}],"version-history":[{"count":6,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/14061\/revisions"}],"predecessor-version":[{"id":14073,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/14061\/revisions\/14073"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/14068"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=14061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=14061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=14061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}