{"id":2445,"date":"2019-07-29T06:39:22","date_gmt":"2019-07-29T03:39:22","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=2445"},"modified":"2019-07-29T06:40:59","modified_gmt":"2019-07-29T03:40:59","slug":"viagra-kanser-tedavisinde-kullanilabilir-mi","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/viagra-kanser-tedavisinde-kullanilabilir-mi\/","title":{"rendered":"Viagra Kanser Tedavisinde Kullan\u0131labilir mi?"},"content":{"rendered":"\n
\"\"

<\/figcaption><\/figure><\/div>\n\n\n\n

Viagra nedir?<\/strong><\/p>\n\n\n\n

Viagra bilind\u011fi \u00fczere erektil disfonksiyonda tedavisinde kullan\u0131lan, Pfizer firmas\u0131 taraf\u0131ndan piyasaya s\u00fcr\u00fclm\u00fc\u015f olan bir ila\u00e7t\u0131r <\/p>\n\n\n\n

 Peki bu ilac\u0131n ilk kullan\u0131m amac\u0131 nedir?<\/strong><\/p>\n\n\n\n

\u0130lk olarak hipertansiyon hastalar\u0131n\u0131n kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrmek i\u00e7in kullan\u0131lmas\u0131 i\u00e7in klinik \u00e7al\u0131\u015fmalara ba\u015fland\u0131\u011f\u0131 ile ilgili haberler olsa da bu \u00e7al\u0131\u015fman\u0131n klinik deneylerinin ba\u015far\u0131 g\u00f6stermemesi ve \u2018\u2019ereksiyon\u2019\u2019 yan etkisi g\u00f6stermeye ba\u015flanmas\u0131yla ilac\u0131n kullan\u0131lma amac\u0131 ba\u015fka bir hal alm\u0131\u015ft\u0131r.<\/p>\n\n\n\n

\u0130la\u00e7 nas\u0131l etki\netmektedir?<\/strong><\/p>\n\n\n\n

\u0130lac\u0131n etken maddesi sildenafil\nsitrat olup bu madde bir PDE5(fosfodiesteraz 5) inhibit\u00f6r\u00fcd\u00fcr. Bu nedenle PDE\u2019den\nbahsetmekte fayda var.<\/p>\n\n\n\n

Fosfodiesteraz enzimleri k\u0131saca PDE olarak an\u0131lmakta olup h\u00fccre i\u00e7i ikinci haberci molek\u00fcller olan cAMP ve cGMP\u2019yi hidrolize ederek par\u00e7alanmalar\u0131na neden olurlar.. \u015eu ana kadar 11 farkl\u0131 izoenzimi farkedilmi\u015f olup etki mekanizmalar\u0131 de\u011fi\u015fkenlik g\u00f6stermektedir.(1) <\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

Peki kanser h\u00fccrelerinde PDE d\u00fczeyleri nas\u0131l?<\/strong><\/p>\n\n\n\n

Alexandra M. Fajardo ve arkada\u015flar\u0131n\u0131n 2014 y\u0131l\u0131nda yay\u0131nlad\u0131klar\u0131 makalede PDE aktivitesinin bir \u00e7ok kanser \u00e7e\u015fidinde artt\u0131\u011f\u0131n\u0131 belirtmi\u015flerdir. (2) Bu makalede PDE aktivasyonunun bir \u00e7ok etkisi bahsedilse de ikinci habercilerin mekanizmalar\u0131 tam olarak ayd\u0131nlat\u0131lamamaktad\u0131r.<\/p>\n\n\n\n

Peki PDE5 inhibit\u00f6rlerinin etkisi nas\u0131l olmaktad\u0131r?<\/strong><\/p>\n\n\n\n

PDE5 inhibit\u00f6rlerinin daha \u00e7ok\nerektil disfonksiyonda kullan\u0131ld\u0131\u011f\u0131 bilinse de ikinci habercileri etkileme\npotansiyeli \u00e7ok fazla oldu\u011fu i\u00e7in bir \u00e7ok hastal\u0131\u011f\u0131n tedavide kullan\u0131labilece\u011fi\nd\u00fc\u015f\u00fcn\u00fclebilir.<\/p>\n\n\n\n

Marialuisa Sponziello ve\narkada\u015flar\u0131n\u0131n 2015 y\u0131l\u0131nda Endocrine dergisinde yay\u0131mlad\u0131\u011f\u0131 makalesinde insan\npapiller tiroid kanserinin a\u015f\u0131r\u0131 derecede PDE5 salg\u0131lad\u0131\u011f\u0131 ve PDE5\ninhibit\u00f6rlerinin bu kanser tiplerinin proliferasyonunu bloke etme yetene\u011fine sahip\noldu\u011funu g\u00f6stermi\u015f olup PDE5 inhibit\u00f6rlerinin tedavide kullan\u0131labilece\u011fini \u00f6nermi\u015flerdir.(3)<\/p>\n\n\n\n

Bianca I. Islam ve arkada\u015flar\u0131n\u0131n 2017 y\u0131l\u0131nda Cancer Prevention Research dergisinde yay\u0131nlanan makalesinde AOM\/DSS etkili fare modellerinde sildenafilin inflamasyona dayal\u0131 kolit olu\u015fumu riskini azaltt\u0131\u011f\u0131n\u0131 belirlemi\u015fledir. Bu \u00e7al\u0131\u015fma sonucunda sildenafilin kanser tedavisinde ter\u00f6patik de\u011feri oldu\u011funu belirtmi\u015flerdir. (4) <\/p>\n\n\n\n

Xiao Long-Mei ve arkada\u015flar\u0131n\u0131n\n2015 y\u0131l\u0131nda American Journal of Cancer Research dergisinde yay\u0131nlad\u0131klar\u0131\nmakalesinde Sildenafilin in vitro ko\u015fullarda koleraktal kanser h\u00fccrelerinin\nb\u00fcy\u00fcmesini inhibe etti\u011fini, kolerektal kanser h\u00fccrelerinde apoptozu\nind\u00fckledi\u011fini bulmu\u015flard\u0131r.(5)<\/p>\n\n\n\n

Anindita Das ve arkada\u015flar\u0131n\u0131n 2014 y\u0131l\u0131nda Pharmacoogy and Therapeutics dergisinde yay\u0131nlad\u0131klar\u0131 makalede PDE5 inhibt\u00f6rlerinin meme kanseri h\u00fccrelerinde se\u00e7ici apoptozu ind\u00fckledi\u011fi belirlenmi\u015ftir.(6)<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

Peki PDE5 inhibit\u00f6rleri kanseri hep iyi y\u00f6nde mi etkiler?<\/strong><\/p>\n\n\n\n

Bahsetti\u011fim \u00e7al\u0131\u015fmalarda \u00e7\u0131kan sonu\u00e7lara ra\u011fmen Miles D. Houslay\u2019in Trends in Cancer dergisinde yazd\u0131\u011f\u0131 yaz\u0131da PDE5 inhibit\u00f6rlerinin melanomu artt\u0131rabilece\u011fi ile ilgili bir yaz\u0131s\u0131 da mevcuttur.(7)<\/p>\n\n\n\n

Peki PDE5\ninhibit\u00f6rleri kanseri hep iyi y\u00f6nde mi etkiler?<\/strong><\/p>\n\n\n\n

Bu yaz\u0131n\u0131n dayanaklar\u0131ndan biri olan Sandeep Dhayade ve arkada\u015flar\u0131n\u0131n 2016 y\u0131l\u0131nda Cell Reports dergisinde yay\u0131nlanan makalesindeki bulgular bu iddiay\u0131 hayli desteklemektedir.(8)<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

Peki Sildenafil kanser tedavisindede kullan\u0131labilir mi, eksiklikler nelerdir?<\/strong><\/p>\n\n\n\n

\u015eu ana kadar yap\u0131lan \u00e7al\u0131\u015fmalar\ngenellikle h\u00fccre hatt\u0131 \u00e7al\u0131\u015fmalar\u0131 \u00fczerindedir. Veritabanlar\u0131ndaki taramalar\u0131ma\ng\u00f6re \u015fu ana kadar insanda yap\u0131lan \u00e7al\u0131\u015fmalar \u00e7ok az olmakla birlikte fareler\n\u00fczerinde denenmi\u015f \u00e7al\u0131\u015fmalar da yetersiz diyebilece\u011fimiz kadar azd\u0131r.<\/p>\n\n\n\n

\u00d6nerilen tedavi se\u00e7eneklerinde\nPDE5 inhibit\u00f6r\u00fc olarak genellikle hep sildenafil \u00f6nerilmi\u015f olup di\u011fer PDE5 inhibit\u00f6rlerinin\ntedavideki etkilerinin hangi d\u00fczeyde etkili oldu\u011fu bilinememektedir. Benzer\n\u00e7al\u0131\u015fmalarda sadece PDE5 inhibit\u00f6rleri de\u011fil di\u011fer PDE inhibit\u00f6rleri de\nkullan\u0131labilir.<\/p>\n\n\n\n

Yukar\u0131da bahsetti\u011fim yap\u0131lan \u00e7al\u0131\u015fma say\u0131lar\u0131n yetersiz olmas\u0131, bizim yan etkilerin neler olabilece\u011fini tam olarak kestirmemizi engellemektedir.  \u00c7\u00fcnk\u00fc PDE inhibit\u00f6rleri \u00e7ok geni\u015f etki mekanizmalar\u0131 \u00fczerinden h\u00fccresel i\u015flevlerin d\u00fczenlenmesinde b\u00fcy\u00fck rolleri olan cGMP ve cAMP d\u00fczeylerini etkilemektedir. Bu d\u00fczeylerin hangi yolaklar \u00fczerinden kanseri nas\u0131l etkileyece\u011fini kestirmek zor g\u00f6z\u00fckmektedir.<\/p>\n\n\n\n

Kaynak\u00e7a<\/strong><\/p>\n\n\n\n

  1. https:\/\/www.turkiyeklinikleri.com\/article\/en-phosphodiesterase-enzymes-and-nhibitors-review-73851.html<\/a><\/li><\/ol>\n\n\n\n

    DO\u0130:10.5336\/pharmsci.2015-47872<\/p>\n\n\n\n

    2) https:\/\/www.mdpi.com\/2072-6694\/6\/1\/436<\/a><\/p>\n\n\n\n

    doi:10.3390\/cancers6010436<\/p>\n\n\n\n

    3)https:\/\/link.springer.com\/article\/10.1007\/s12020-015-0586-x<\/a>
    \nDOI 10.1007\/s12020-015-0586-x<\/p>\n\n\n\n

    4) http:\/\/cancerpreventionresearch.aacrjournals.org\/content\/10\/7\/377.long<\/a><\/p>\n\n\n\n

    10.1158\/1940-6207.CAPR-17-0015<\/p>\n\n\n\n

    5)\nhttp:\/\/www.ajcr.us\/AJCR_V5N11.html<\/a><\/p>\n\n\n\n

    \nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4697679\/#__ffn_sectitle\n<\/div><\/figure>\n\n\n\n

    6) https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0163725814001892?via%3Dihub<\/a><\/p>\n\n\n\n

    \nhttps:\/\/doi.org\/10.1016\/j.pharmthera.2014.10.003\n<\/div><\/figure>\n\n\n\n

    7) https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S240580331600039X?via%3Dihub<\/a><\/p>\n\n\n\n

    \nhttps:\/\/doi.org\/10.1016\/j.trecan.2016.02.007\n<\/div><\/figure>\n\n\n\n

    8) https:\/\/www.cell.com\/cell-reports\/comments\/S2211-1247(16)30131-0<\/a><\/p>\n\n\n\n

    \nhttps:\/\/doi.org\/10.1016\/j.celrep.2016.02.028\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"

    Viagra nedir? Viagra bilind\u011fi \u00fczere erektil disfonksiyonda tedavisinde kullan\u0131lan, Pfizer firmas\u0131 taraf\u0131ndan piyasaya s\u00fcr\u00fclm\u00fc\u015f olan bir ila\u00e7t\u0131r  Peki bu ilac\u0131n<\/p>\n","protected":false},"author":54,"featured_media":2449,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,5,165],"tags":[],"acf":[],"views":2118,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/2445"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=2445"}],"version-history":[{"count":10,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/2445\/revisions"}],"predecessor-version":[{"id":2464,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/2445\/revisions\/2464"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/2449"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=2445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=2445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=2445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}