{"id":2481,"date":"2019-07-29T22:42:40","date_gmt":"2019-07-29T19:42:40","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=2481"},"modified":"2019-07-29T22:42:43","modified_gmt":"2019-07-29T19:42:43","slug":"cilt-yenilenmesinin-sirri-cozuluyor-mu","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/gunceller\/cilt-yenilenmesinin-sirri-cozuluyor-mu\/","title":{"rendered":"Cilt Yenilenmesinin S\u0131rr\u0131 \u00c7\u00f6z\u00fcl\u00fcyor mu?"},"content":{"rendered":"\n

V\u00fccudumuzun her yap\u0131s\u0131nda oldu\u011fu gibi cildimiz de kendisini yenilemeye meyillidir. Hatta bu konu cilt i\u00e7in daha hayatidir \u00e7\u00fcnk\u00fc cildimizi v\u00fccudu koruyan bir z\u0131rh gibi d\u00fc\u015f\u00fcn\u00fcrsek her zaman sa\u011flam olmas\u0131 gerekir. Nature Communication\u2019da yay\u0131mlanan bir makaleye g\u00f6re derimizin bu rejenerasyonu nas\u0131l ger\u00e7ekle\u015ftirdi\u011fi ke\u015ffedildi.<\/p>\n\n\n\n

Ya\u015fland\u0131k\u00e7a cildimizdeki koyu renklenmeler ve k\u0131r\u0131\u015f\u0131kl\u0131klar artar. Bunlar kronik ya\u015flanma olarak adland\u0131rd\u0131\u011f\u0131m\u0131z epidermal ve dermal de\u011fi\u015fiklikler sonucu olu\u015fur. Ancak G\u00fcne\u015f\u2019ten gelen UV \u0131\u015f\u0131nlar\u0131 ciltteki bu ya\u015flanmay\u0131 h\u0131zland\u0131r\u0131r ve kronik ya\u015flanmadan farkl\u0131 baz\u0131 belirtilere sebep olabilir. Buna da Fotoya\u015flanma deriz. Lazer tedavisi fotoya\u015flanma tedavisinde rutin olarak kullan\u0131l\u0131r. B\u00f6ylece daha gen\u00e7 bir cilt ama\u00e7lan\u0131r.<\/p>\n\n\n\n

\"\"
Resimdeki ki\u015fi 28 y\u0131l t\u0131r \u015fof\u00f6rl\u00fc\u011f\u00fc yapm\u0131\u015f. Y\u00fcz\u00fcn\u00fcn sol k\u0131sm\u0131 g\u00fcne\u015fe daha \u00e7ok maruz kalm\u0131\u015f. Fotoya\u015flanman\u0131n belirgin etkisi dolay\u0131s\u0131yla daha derin k\u0131r\u0131\u015f\u0131kl\u0131klar olu\u015fmu\u015f.<\/figcaption><\/figure>\n\n\n\n

Sedef hastal\u0131\u011f\u0131 ve akne gibi cilt hastal\u0131klar\u0131n\u0131n tedavisinde kullan\u0131lan A vitamini t\u00fcrevi Retinoik Asit ise yine cilt gen\u00e7le\u015fmesi i\u00e7in kullan\u0131lan ba\u015fl\u0131ca tedavi y\u00f6ntemidir. Deride keratinosit ve fibroblastlar\u0131n \u00e7o\u011falmas\u0131n\u0131 uyar\u0131r, fibroblastlar taraf\u0131ndan sentezlenen kollajen dermis yap\u0131s\u0131n\u0131 d\u00fczenler. <\/p>\n\n\n\n

\u0130\u015fte farkl\u0131 bu iki tedavi y\u00f6nteminin asl\u0131nda ayn\u0131 yolak\n\u00fczerinden \u00e7al\u0131\u015ft\u0131\u011f\u0131 ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan kan\u0131tlanm\u0131\u015f oldu.<\/p>\n\n\n\n

Johns Hopkins \u00dcniversitesi T\u0131p Fak\u00fcltesi’nden dermatoloji profes\u00f6r\u00fc Luis Garza ve ekibi taraf\u0131ndan yap\u0131lan ara\u015ft\u0131rmada 17 dene\u011fe lazer tedavisi uyguland\u0131. Tedavi bitiminden 1 hafta sonra deneklerden al\u0131nan deri \u00f6rneklerine biyopsi uyguland\u0131 ve retinoik asit art\u0131\u015f\u0131yla beraber dsRNA larda da anlaml\u0131 bir art\u0131\u015f g\u00f6zlemlendi. <\/p>\n\n\n\n

\u0130nsan keratinositlerinden olu\u015fan h\u00fccre k\u00fclt\u00fcr\u00fcnde yap\u0131lan\nbir di\u011fer deneyde eksojen olarak verilen dsRNA lar sonucu retinoik asit\nmiktar\u0131nda yine art\u0131\u015f g\u00f6r\u00fcld\u00fc. <\/p>\n\n\n\n

Bu deneyler sonucunda dsRNAlar ile retinoik asit birikimi aras\u0131nda bir ili\u015fki oldu\u011fu bulundu. Prof. Garza \u201cBu bulgular iyile\u015fmeyi art\u0131racak, izleri \u00f6nleyecek ve umar\u0131z ki gen\u00e7le\u015fmeyi sa\u011flayacak bir dsRNA\/retinoik asit kombinasyonu, tedavi stratejisini ortaya \u00e7\u0131karacak\u201d dedi. <\/p>\n\n\n\n

Ancak mekanizma tam olarak bilinmiyordu. Hayvanlar \u00fczerinde\nyap\u0131lan deneyler sonucu k\u0131smen de olsa baz\u0131 cevaplar getirildi.<\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar fareler \u00fczerinde yapt\u0131klar\u0131 deneylerde dsRNA lar\u0131n retinoik asit sentezini ind\u00fcklemek i\u00e7in TLR3 resept\u00f6rlerini aktive etti\u011fini g\u00f6sterdi. Burada durum ilgin\u00e7 bir hal ald\u0131 \u00e7\u00fcnk\u00fc TLR (Toll Like Resept\u00f6r) denilen bu resept\u00f6rlerin sadece antiviral ve antit\u00fcm\u00f6ral oldu\u011fu biliniyor, \u015fu ana kadar cilt yenilenmesinde bir rol\u00fc oldu\u011fu d\u00fc\u015f\u00fcn\u00fclm\u00fcyordu. Bu incelemeden sonra TLR3\u2019\u00fcn yaralanma sonras\u0131 rejenerasyonda iyi bir dsRNA resept\u00f6r\u00fc oldu\u011fu anla\u015f\u0131ld\u0131. <\/p>\n\n\n\n

Ke\u015ffedilen bu mekanizma ile retinoik asitin endojen sentezinin ind\u00fcklenmesinin, v\u00fccuda eksojen olarak verilmesinden daha etkili olaca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyor.<\/p>\n\n\n\n

Kaynak\u00e7a:<\/p>\n\n\n\n

https:\/\/www.nature.com\/articles\/s41467-019-10811-y<\/a>
<\/p>\n\n\n\n

https:\/\/www.medicalnewstoday.com\/articles\/325782.php<\/a> <\/p>\n\n\n\n

http:\/\/www.dermatoz.org\/2015\/3\/dermatoz15063d1.pdf <\/p>\n\n\n\n

https:\/\/www.timeturk.com\/tr\/2012\/06\/02\/yuzunun-bir-yani-69-diger-yani.html<\/a> <\/p>\n","protected":false},"excerpt":{"rendered":"

V\u00fccudumuzun her yap\u0131s\u0131nda oldu\u011fu gibi cildimiz de kendisini yenilemeye meyillidir. Hatta bu konu cilt i\u00e7in daha hayatidir \u00e7\u00fcnk\u00fc cildimizi v\u00fccudu<\/p>\n","protected":false},"author":57,"featured_media":2487,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[165],"tags":[310,313,311,316,315,314,312],"acf":[],"views":664,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/2481"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/57"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=2481"}],"version-history":[{"count":4,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/2481\/revisions"}],"predecessor-version":[{"id":2490,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/2481\/revisions\/2490"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/2487"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=2481"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=2481"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=2481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}