{"id":3605,"date":"2019-10-12T10:17:51","date_gmt":"2019-10-12T07:17:51","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=3605"},"modified":"2019-10-12T10:19:44","modified_gmt":"2019-10-12T07:19:44","slug":"2019-nobel-tip-fizyoloji-odulu","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/2019-nobel-tip-fizyoloji-odulu\/","title":{"rendered":"2019 NOBEL TIP\/F\u0130ZYOLOJ\u0130 \u00d6D\u00dcL\u00dc"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" width=\"1024\" height=\"1024\" src=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-1024x1024.png\" alt=\"\" class=\"wp-image-3612\" srcset=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-1024x1024.png 1024w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-150x150.png 150w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-250x250.png 250w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-125x125.png 125w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-110x110.png 110w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-420x420.png 420w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/Ekran-Resmi-2019-10-07-14.15.36-5-768x768.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Takvimime aylar \u00f6ncesinden 7 Ekim 2019 saat 12:15\u2019e bir hat\u0131rlatma girmi\u015ftim ve o g\u00fcn geldi \u00e7att\u0131.<\/p>\n\n\n\n<p>\u00c7ocuk hematolojisi prati\u011fimden \u00e7\u0131k\u0131p hemen dermatoloji binas\u0131n\u0131n \u00f6n\u00fcndeki banklarda yerimi kapt\u0131m. Bilgisayar\u0131m\u0131 a\u00e7t\u0131m ve canl\u0131 olarak \u00f6d\u00fcl t\u00f6renini izlemeye koyuldum. Bekledi\u011fimin aksine uzun giri\u015f konu\u015fmalar\u0131 olmadan do\u011frudan \u00f6d\u00fcl\u00fcn sahipleri a\u00e7\u0131kland\u0131. Kazananlar\u0131n \u00f6nce \u0130sve\u00e7 dilinde sonra \u0130ngilizce anons edilmesi de dikkatimi \u00e7ekti do\u011frusu.<\/p>\n\n\n\n<p>\u0130sterseniz d\u00fcnyan\u0131n en prestijli \u00f6d\u00fcllerinden birine lay\u0131k olan bu \u00e7al\u0131\u015fmay\u0131 incelemeye koyulal\u0131m:<\/p>\n\n\n\n<p>Bu y\u0131lki \u00f6d\u00fcl\u00fcn sahipleri:<\/p>\n\n\n\n<p><strong>Gregg L. Semenza<\/strong> , Johns Hopkins University<\/p>\n\n\n\n<p><strong>Sir Peter J.Ratcliffe<\/strong> , Oxford University Francis Crick Institute<\/p>\n\n\n\n<p><strong>William G. Kaelin, Jr.<\/strong> &#8211; Dana Farber Cancer Institute Harvard University<\/p>\n\n\n\n<p>olmak \u00fczere \u00fc\u00e7 ara\u015ft\u0131rmac\u0131d\u0131r.<\/p>\n\n\n\n<p>\u00d6d\u00fcllendirilen \u00e7al\u0131\u015fmalar\u0131n konusunu bir c\u00fcmlede \u00f6zetlemek istersek <strong>&#8216;h\u00fccrelerin oksijen miktar\u0131na g\u00f6re kendilerini adapte etme mekanizmas\u0131ndaki ke\u015fif&#8217;<\/strong> diyebiliriz.<\/p>\n\n\n\n<p>Ke\u015ffedilen mekanizman\u0131n detaylar\u0131na gelecek olursak:<\/p>\n\n\n\n<p>Hipoksi durumunda b\u00f6breklerimizde, eritropetin(EPO) hormonunun salg\u0131land\u0131\u011f\u0131n\u0131 biliyoruz.<\/p>\n\n\n\n<p>1995\u2019li y\u0131llarda; Semenza, EPO geninde HRE(hypoxia response element)&#8217;i tan\u0131ml\u0131yor. Sonras\u0131nda bu genden transkripsiyon fakt\u00f6r\u00fcn\u00fc elde ediyor. Ve bu protein kompleksine HIF-1&nbsp;alfa&nbsp;ad\u0131n\u0131 veriyor.<br><\/p>\n\n\n\n<p>(Bu protein t\u00fcm bu s\u00fcre\u00e7teki anahtar d\u00fczenleyici, oksijene hassas bir protein. \u015e\u00f6yle ki:<\/p>\n\n\n\n<p>-normoksi (normal oksijen miktar\u0131) durumunda h\u00fccrede bulunuyor<\/p>\n\n\n\n<p>-hipoksi durumunda proteozomal degredasyonla ortadan kalk\u0131yor)<\/p>\n\n\n\n<p>Bu s\u0131ralada Kalein, kanserle ilgili olan VHL geniyle \u00e7al\u0131\u015f\u0131rken VHL i\u00e7ermeyen h\u00fccrelerde hipoksi ile ind\u00fcklenebilir gen ekspresyonunun artt\u0131\u011f\u0131n\u0131 ke\u015ffediyor.<\/p>\n\n\n\n<p>Sonras\u0131nda, Redcliff HIF-1&nbsp;alfa\u2019n\u0131n degrede olmas\u0131 i\u00e7in VHL genine ihtiya\u00e7 duyuldu\u011funu ke\u015ffediyor.<\/p>\n\n\n\n<p>3 ara\u015ft\u0131rmac\u0131n\u0131n \u00e7al\u0131\u015fmalar\u0131n\u0131 bir araya getirdi\u011fimizde, mekanizma \u015fu \u015fekilde:<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" width=\"1024\" height=\"580\" src=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10-1024x580.jpg\" alt=\"\" class=\"wp-image-3615\" srcset=\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10-1024x580.jpg 1024w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10-400x227.jpg 400w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10-768x435.jpg 768w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10-110x62.jpg 110w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10-420x238.jpg 420w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10-759x430.jpg 759w, https:\/\/blog.ulubat.org\/wp-content\/uploads\/2019\/10\/IMG_0877-10.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>H\u00fccrede yeterli oksijen bulundu\u011fu zaman, HIF-1&nbsp;alfa&nbsp;ekspresyonu art\u0131yor. Sonra, HIF-1alfa&#8217; daki&nbsp;&nbsp;iki prolin aminoasidi hidroksillenerek VHL kompleksi taraf\u0131ndan tan\u0131n\u0131r hale gelip degrede ediliyor.<\/p>\n\n\n\n<p>\u00d6d\u00fcl\u00fcn a\u00e7\u0131klamas\u0131ndan sonra gazeteciler bu ke\u015ffin insanl\u0131\u011fa ne gibi faydalar\u0131 olaca\u011f\u0131n\u0131 sordular. Nobel komitesinden yetkililer, anemi tedavisi gibi bir\u00e7ok hastal\u0131kta bu ke\u015ffin fayda sa\u011flayaca\u011f\u0131n\u0131 belirttiler. Mesela, anemisi olan hastalarda,y\u00fcksek rak\u0131mda ya\u015f\u0131yan hastalarda HIF- 1&nbsp;alfa&nbsp;ekspresyonunu artt\u0131rarak bir tedavi sa\u011flayabiliriz. Fakat ayn\u0131 zamanda bu h\u00fccrelerin t\u00fcm\u00f6r h\u00fccresine de d\u00f6n\u00fc\u015fmesine sebep olabiliriz,dolay\u0131s\u0131yla dikkatli olmam\u0131z laz\u0131m.<\/p>\n\n\n\n<p>Onun haricinde, ni\u00e7in bu ara\u015ft\u0131rmac\u0131lar\u0131n \u00f6d\u00fcle lay\u0131k g\u00f6r\u00fcld\u00fc\u011f\u00fc sorusuna temel olarak, Alfred Nobel\u2019in direktifleri do\u011frultusunda \u2018ke\u015fif\u2019lere \u00f6d\u00fcl verdiklerini ve bu ke\u015ffin textbook\u2019lara girecek \u00e7ok temel bir ke\u015fif oldu\u011fu belirtildi.<\/p>\n\n\n\n<p>Komik bir not:<\/p>\n\n\n\n<p>Bu sabah \u00f6d\u00fcl sahiplerini telefonla arayarak haber veren nobel komitesi Kaelin\u2019inin telefonunu bulam\u0131yor. K\u0131zkarde\u015fine ula\u015f\u0131yorlar.O da iki telefon numaras\u0131 veriyor. Komite ilk telefonu ar\u0131yor \u2018Kalein\u2019le mi g\u00f6r\u00fc\u015f\u00fcyorum?\u2019 diyorlar kar\u015f\u0131 taraf \u2018Hay\u0131r, ben de\u011filim yanl\u0131\u015f numara\u2019 diyor ve ikinci telefonda kendisine ula\u015f\u0131l\u0131yor. Bence, ilk telefonun sahibi, d\u00fcnya tarihine yanl\u0131\u015fl\u0131kla aranan en \u015fansl\u0131 ki\u015fi olarak&nbsp;&nbsp;ge\u00e7mi\u015f bulunuyor.<\/p>\n\n\n\n<p><div><br><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Takvimime aylar \u00f6ncesinden 7 Ekim 2019 saat 12:15\u2019e bir hat\u0131rlatma girmi\u015ftim ve o g\u00fcn geldi \u00e7att\u0131. \u00c7ocuk hematolojisi prati\u011fimden \u00e7\u0131k\u0131p<\/p>\n","protected":false},"author":144,"featured_media":3614,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[453],"acf":[],"views":805,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/3605"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/144"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=3605"}],"version-history":[{"count":9,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/3605\/revisions"}],"predecessor-version":[{"id":3617,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/3605\/revisions\/3617"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/3614"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=3605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=3605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=3605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}