{"id":3872,"date":"2019-10-23T19:45:36","date_gmt":"2019-10-23T16:45:36","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=3872"},"modified":"2019-10-23T12:56:27","modified_gmt":"2019-10-23T09:56:27","slug":"sihirli-mermiler-ve-hedeflenmis-ilaclarla-yan-etkisiz-kanser-tedavisi-mumkun-olabilir","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/sihirli-mermiler-ve-hedeflenmis-ilaclarla-yan-etkisiz-kanser-tedavisi-mumkun-olabilir\/","title":{"rendered":"S\u0130H\u0130RL\u0130 MERM\u0130LER VE HEDEFLENM\u0130\u015e \u0130LA\u00c7LARLA YAN ETK\u0130S\u0130Z KANSER TEDAV\u0130S\u0130 M\u00dcMK\u00dcN OLAB\u0130L\u0130R"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Bir banka soyguncusunun soygun esnas\u0131nda rehinelerle birlikte bankan\u0131n i\u00e7inde oldu\u011funu varsayal\u0131m soyguncuyu nas\u0131l etkisiz hale getirirsiniz; <\/p>\n\n\n\n

A) soyguncunun oldu\u011fu binay\u0131 yok ederek <\/p>\n\n\n\n

B) spesifik olarak soyguncuyu hedef alarak<\/p>\n\n\n\n

Kanser tedavisinde kemoterapi uygulamak ile A se\u00e7ene\u011fi aras\u0131nda b\u00fcy\u00fck bir benzerlik oldu\u011fu a\u015fik\u00e2r. Tam bu a\u015famada, \u00e7evre dokulara zarar vermeyecek \u015fekilde t\u00fcm\u00f6re hedeflenmi\u015f ila\u00e7larla tedavi devreye giriyor ama \u00f6ncesinde kemoterapiden bahsedelim.
<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Kemoterapi, kanser hastalar\u0131 i\u00e7in tedavinin uzunca bir s\u00fcre ana y\u00f6ntemi olmu\u015ftur. Bununla birlikte ba\u015far\u0131 oran\u0131, ila\u00e7lar\u0131n t\u00fcm\u00f6r dokusuna s\u0131n\u0131rl\u0131 eri\u015fimi, toksisite, \u00e7oklu ila\u00e7 direncinin geli\u015fmesi gibi sebeplerden \u00f6t\u00fcr\u00fc d\u00fc\u015f\u00fck kal\u0131yor. Son y\u0131llarda t\u00fcm\u00f6r biyolojisinin daha iyi anla\u015f\u0131lmas\u0131yla farkl\u0131 nanosistemler ve biyokonj\u00fcgatlar kullan\u0131larak yap\u0131lan hedefli ila\u00e7 vermek gibi yakla\u015f\u0131mlar, minimum d\u00fczeyde yan etkiyle, kanser tedavisini m\u00fcmk\u00fcn k\u0131l\u0131yor.<\/p>\n\n\n\n

Kemoterapinin hedeflenmi\u015f ila\u00e7 tedavisine g\u00f6re verimsiz kalmas\u0131n\u0131n nedenleri aras\u0131nda antineoplastik ajanlar\u0131n t\u00fcm\u00f6re eri\u015fememesi, daha y\u00fcksek dozlar gerektirmesi ve bu ajanlar\u0131n se\u00e7ici olmayan do\u011fas\u0131n\u0131n ciddi toksisiteye neden olmas\u0131 da yer al\u0131yor. Bu nedenle, hedefli ila\u00e7 da\u011f\u0131t\u0131m\u0131, t\u00fcm\u00f6r b\u00f6lgesinde terap\u00f6tik olarak etkili ila\u00e7 konsantrasyonlar\u0131n\u0131 ayarlayarak kanser tedavisini yan etkisiz bi\u00e7imde m\u00fcmk\u00fcn k\u0131lmak i\u00e7in b\u00fcy\u00fck bir potansiyele sahiptir.<\/p>\n\n\n\n


<\/p>\n\n\n\n

\"\"
Akci\u011fer kanseriyle ili\u015fkili EGFR, ALK genlerinin mutasyon y\u00fczdelerinin di\u011fer genlerin mutasyon y\u00fczdeleriyle kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131<\/figcaption><\/figure>\n\n\n\n

Akci\u011fer kanserlerinde \u0131\u015f\u0131k mikroskopisi ile yap\u0131lan tan\u0131n\u0131n hemen ard\u0131ndan EGFR, ALK, ROS denilen genlerdeki bozukluklar ara\u015ft\u0131r\u0131l\u0131yor. E\u011fer b\u00f6yle bir genetik bozukluk saptan\u0131rsa bu hastalara kemoterapi verilmeden ba\u015flanan ak\u0131ll\u0131 molek\u00fcllerle 2 y\u0131l\u0131n \u00fcst\u00fcnde hastal\u0131k kontrol\u00fc elde edilebildi\u011fi g\u00f6zlenmi\u015ftir. Bug\u00fcn hedefli tedavilerde kullan\u0131lan ikinci ve \u00fc\u00e7\u00fcnc\u00fc ku\u015fak molek\u00fcller t\u00fcm\u00f6r\u00fcn tedaviye diren\u00e7 geli\u015ftirdi\u011fi durumlarda dahi %30-%40 oran\u0131nda yan\u0131t elde edilebildi\u011fi g\u00f6zlenmi\u015ftir.<\/p>\n\n\n\n

\"\"
Bir nanomerminin boyut, i\u00e7erik, y\u00fczey fonksiyonu ve hedefini g\u00f6steren bir ill\u00fcstrasyon<\/figcaption><\/figure>\n\n\n\n

Baz\u0131 biyolojik tedavi ajanlar\u0131n\u0131n v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sistemi taraf\u0131ndan \u00fcretilen birtak\u0131m molek\u00fcllerin kanserli h\u00fccrelerde bulunan baz\u0131 hedeflere kar\u015f\u0131 kullan\u0131labildi\u011fi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. \u2018Sihirli mermiler\u2019 \u015feklinde adland\u0131r\u0131lan bu biyolojik tedavi ajanlar\u0131 lenf bezi kanserlerinde, meme kanserlerinde, kal\u0131n ba\u011f\u0131rsak kanserlerinde kullan\u0131labilir. Bu sihirli mermilerin klasik tedavilere eklendi\u011finde dahi kemoterapi veya radyoterapinin etkisini %30 ile %50 oran\u0131nda art\u0131rma potansiyelinin oldu\u011fu g\u00f6zlemlenmi\u015ftir. Bu teknoloji, sadece kanser de\u011fil tip 1 diyabet gibi modern toplumlar\u0131n en b\u00fcy\u00fck problemlerinden birine daha \u00e7\u00f6z\u00fcm olma potansiyeline sahip. Ak\u0131ll\u0131 molek\u00fcl ve kontroll\u00fc sal\u0131m sayesinde tip 1 diyabet hastalar\u0131n\u0131n damarlar\u0131na yerle\u015ftirilen veri aktarmal\u0131 ak\u0131ll\u0131 mikro\u00e7ip sayesinde kan \u015fekerinin sabit tutulup d\u0131\u015f ortama anl\u0131k verinin g\u00f6nderilebildi\u011fi deney \u00e7al\u0131\u015fmalar\u0131na d\u00fcnya \u00e7ap\u0131nda \u015fahit oluyoruz. Umuyorum ki bu teknoloji de prehistorik \u00e7a\u011f\u0131n\u0131 a\u015f\u0131p bilim okyanusunun u\u00e7suz bucaks\u0131z sular\u0131na kar\u0131\u015fabilir.<\/p>\n\n\n\n

Kaynak\u00e7a:<\/p>\n\n\n\n

Konno, T. Hepatom i\u00e7in Kemoterapiyi Hedefleme: Lipiodol’de \u00c7\u00f6z\u00fcnen Antikanser \u0130la\u00e7lar\u0131n Arteriyel Uygulamas\u0131.\u00a0 Eur J Cancer 28, 403-409.<\/p>\n\n\n\n

Chari, R. V. Kemoterap\u00f6tiklerin Hedeflenmi\u015f Sunumu: \u00d6n ila\u00e7 tedavisi.\u00a0 Adv Drug Deliv Rev 31, 89-104 (1998).<\/p>\n\n\n\n

https:\/\/encrypted-tbn0.gstatic.com\/images?q=tbn%3AANd9GcTpJ5X8ac2fVXpvfN0uP-YkMoktlXYn1sQrpgVhcMduHgcnzj20 <\/p>\n\n\n\n

https:\/\/sarkac.org\/wp-content\/uploads\/2019\/05\/shutterstock_1354971455-k-696×392.jpg
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https:\/\/encrypted-tbn0.gstatic.com\/images?q=tbn%3AANd9GcS70w3ab6O2DdzClhKCA_s6F6uRDPll1kWYI7SUCRNUyGd72h_r <\/p>\n\n\n\n

https:\/\/encrypted-tbn0.gstatic.com\/images?q=tbn%3AANd9GcSYSD1NNgQRk-PTyxtTlzzchXX9mEktOq_jL2gMO08Q_axBHwdA <\/p>\n\n\n\n

https:\/\/www.google.com\/amp\/s\/indigodergisi.com\/2018\/02\/kanser-tedavi-immunoterapi-likid-biyopsi-sihirli-mermi\/amp\/<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Bir banka soyguncusunun soygun esnas\u0131nda rehinelerle birlikte bankan\u0131n i\u00e7inde oldu\u011funu varsayal\u0131m soyguncuyu nas\u0131l etkisiz hale getirirsiniz;  A) soyguncunun oldu\u011fu binay\u0131<\/p>\n","protected":false},"author":191,"featured_media":3877,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[539,538],"acf":[],"views":860,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/3872"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/191"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=3872"}],"version-history":[{"count":9,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/3872\/revisions"}],"predecessor-version":[{"id":3885,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/3872\/revisions\/3885"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/3877"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=3872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=3872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=3872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}