{"id":7934,"date":"2020-10-15T19:19:33","date_gmt":"2020-10-15T16:19:33","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=7934"},"modified":"2020-10-15T19:19:35","modified_gmt":"2020-10-15T16:19:35","slug":"guncel-bir-biyografi-jennifer-doudna-ve-emmanuelle-charpentier","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/guncel-bir-biyografi-jennifer-doudna-ve-emmanuelle-charpentier\/","title":{"rendered":"G\u00dcNCEL B\u0130R B\u0130YOGRAF\u0130: \u201cJennifer Doudna\u201d ve \u201cEmmanuelle Charpentier\u201d"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

2020 Nobel Kimya \u00d6d\u00fcl\u00fc, genom\nkurgulamas\u0131na olanak sa\u011flayan \u00e7al\u0131\u015fmalar y\u00fcr\u00fcten mikrobiyolog Emmanuelle\nCharpentier ile biyokimyac\u0131 Jennifer A. Doudna’ya verildi. DNA zincirlerini\nkesmeye ve yeniden birle\u015ftirmeye olanak sa\u011flayan \u201cCRISPR\/Cas9<\/strong>\u201d isimli genetik makas\u0131n (genetic scissors) geli\u015ftirilmesi,\nkanser ve kal\u0131tsal hastal\u0131klar\u0131n tedavileri i\u00e7in umut vadetmektedir. Gelin,\nbilime b\u00fcy\u00fck katk\u0131lar sa\u011flayan bu iki bilim insan\u0131n\u0131 daha yak\u0131ndan tan\u0131yal\u0131m.<\/p>\n\n\n\n

\"\"

Emmanuelle Charpentier<\/em> <\/figcaption><\/figure>\n\n\n\n

Emmanuelle Charpentier\u2019a Dair:<\/em><\/h2>\n\n\n\n

11 Aral\u0131k 1968 tarihinde Fransa\u2019da do\u011fmu\u015ftur. Paris’teki\nPierre ve Marie Curie \u00dcniversitesinde (g\u00fcn\u00fcm\u00fczde Sorbonne \u00dcniversitesi Fen\nFak\u00fcltesi) biyokimya, mikrobiyoloji ve genetik okumu\u015ftur. 1992-1995 y\u0131llar\u0131\naras\u0131nda Institut Pasteur’da doktoras\u0131n\u0131 yapm\u0131\u015ft\u0131r. Charpentier’in doktora\nprojesi, antibiyotik direnciyle ilgili molek\u00fcler mekanizmalar \u00fczerinedir.<\/p>\n\n\n\n

Daha sonra gitti\u011fi Amerika Birle\u015fik Devletleri’nde New\nYork’taki Rockefeller \u00dcniversitesi kadrosunda ara\u015ft\u0131rmac\u0131 olarak yer alm\u0131\u015ft\u0131r.\nBu s\u00fcre zarf\u0131nda Charpentier, mikrobiyolog Elaine Tuomanen’in laboratuvar\u0131nda\n\u00e7al\u0131\u015fm\u0131\u015ft\u0131r. Laboratuvarda, patojen Streptococcus pneumoniae<\/em>‘nin\ngenomunu de\u011fi\u015ftirmek i\u00e7in mobil genetik elementlerin nas\u0131l kulland\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rm\u0131\u015ft\u0131r.\nCharpentier ayr\u0131ca S. pneumoniae<\/em>‘deki Vankomisin direncinin\nara\u015ft\u0131r\u0131lmas\u0131 ile ilgili \u00e7al\u0131\u015fmalarda yer alm\u0131\u015ft\u0131r.<\/p>\n\n\n\n

\"\"

Jennifer Doudna<\/em> <\/figcaption><\/figure>\n\n\n\n

Jennifer Doudna\u2019ya Dair:<\/em><\/h2>\n\n\n\n

19 \u015eubat 1964 tarihinde, Amerika\u2019da do\u011fmu\u015ftur. 1985\u2019te\nPomona College’dan\nmezun olmu\u015f ve sonras\u0131nda\ndoktora derecesi alm\u0131\u015ft\u0131r. UC Berkeley’deki profes\u00f6rl\u00fc\u011f\u00fcn\u00fcn yan\u0131 s\u0131ra,\nYenilik\u00e7i Genomik Enstit\u00fcs\u00fc’n\u00fcn y\u00f6netim kurulu ba\u015fkan\u0131, Lawrence Berkeley\nUlusal Laboratuvar\u0131’nda fak\u00fclte bilimcisi, Gladstone Enstit\u00fcleri’nde k\u0131demli\nara\u015ft\u0131rmac\u0131 ve yard\u0131mc\u0131 ve UC San Francisco’da h\u00fccresel ve molek\u00fcler\nfarmakoloji profes\u00f6r\u00fcd\u00fcr.1997’den beri Howard Hughes T\u0131p Enstit\u00fcs\u00fc’nde\nara\u015ft\u0131rmac\u0131 olarak \u00e7al\u0131\u015fmaktad\u0131r.<\/p>\n\n\n\n

2012’de Emmanuelle Charpentier ile bakterilerin d\u0131\u015f etmenlere kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131nda rol oynayan CRISPR\/Cas9’un herhangi bir genomun programlanabilir bir \u015fekilde de\u011fi\u015ftirilip d\u00fczenlenmesi i\u00e7in kullan\u0131labilece\u011fini ke\u015ffetmi\u015flerdir. Sonras\u0131nda \u00e7e\u015fitli ara\u015ft\u0131rma ekipleri olu\u015fturulmu\u015f ve temel biyolojik metotlarla Orak H\u00fccreli Anemi, Kistik Fibrozis gibi hastal\u0131klar\u0131n tedavisine y\u00f6nelik ara\u015ft\u0131rmalarda bu ke\u015fiften yararlan\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n

Doudna, biyokimya ve geneti\u011fe katk\u0131lar\u0131 nedeniyle \u00e7e\u015fitli \u00f6d\u00fcller kazanm\u0131\u015ft\u0131r. 2000 y\u0131l\u0131nda bilim d\u00fcnyas\u0131nda tan\u0131nmas\u0131n\u0131 sa\u011flayan X \u0131\u015f\u0131n\u0131 kristalografisi arac\u0131l\u0131\u011f\u0131yla Ribozim\u2019in yap\u0131s\u0131n\u0131 ke\u015ffetmi\u015f ve Alan T. Waterman \u00d6d\u00fcl\u00fc’n\u00fc alm\u0131\u015ft\u0131r. 2002 y\u0131l\u0131nda Amerika Birle\u015fik Devletleri Ulusal Bilimler Akademisi\u2019ne se\u00e7ilmi\u015ftir. 2015 y\u0131l\u0131nda CRISPR\/Cas9 teknolojisini geli\u015ftirmeleri nedeniyle Charpentier ile \u201cBreakthrough Prize in Life Sciences\u201da lay\u0131k g\u00f6r\u00fclm\u00fc\u015flerdir. Ayn\u0131 y\u0131l Time dergisinin derledi\u011fi \u201c100 most influential people\u201d listesinde yer alm\u0131\u015ft\u0131r.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Son Olarak Bizlere Dair:<\/em><\/h2>\n\n\n\n

Sizlere her ay bir biyografi yaz\u0131s\u0131 yazarak de\u011ferli\nbilim insanlar\u0131n\u0131n hayatlar\u0131na de\u011finiyoruz. Bizler \u015fu anda ke\u015fifleriyle bizlere\n\u0131\u015f\u0131k tutan bilim insanlar\u0131n\u0131n ayak izlerini elimizden geldi\u011fince takip\nediyoruz. Onlar\u0131n hayatlar\u0131ndan bir \u015feyler \u00f6\u011frendi\u011fimiz zaman y\u00fcre\u011fimizde\nbilime dair bir \u0131\u015f\u0131k yan\u0131yorsa ne mutlu bize.  Bir g\u00fcn t\u0131pk\u0131 Jennifer Doudna ve Emmanuelle\nCharpentier gibi insanlar\u0131n hayatlar\u0131na dokunacak ke\u015fifler yaparak biz de bu\n\u0131\u015f\u0131\u011f\u0131n bir par\u00e7as\u0131 olabiliriz yeter ki \u00e7ok okuyup, \u00e7ok \u00f6\u011frenelim. En \u00f6nemlisi\nde kalplerimizdeki \u0131\u015f\u0131\u011f\u0131 hi\u00e7 s\u00f6nd\u00fcrmeyelim.<\/p>\n\n\n\n

KAYNAKLAR:<\/em><\/p>\n\n\n\n

Jennifer Doudna. Al\u0131nd\u0131\u011f\u0131 yer:<\/em><\/p>\n\n\n\n

https:\/\/tr.wikipedia.org\/wiki\/Jennifer_Doudna<\/a><\/p>\n\n\n\n

Emmanuelle Charpentier.Al\u0131nd\u0131\u011f\u0131 yer:<\/em><\/p>\n\n\n\n

https:\/\/tr.wikipedia.org\/wiki\/Emmanuelle_Charpentier<\/a><\/p>\n\n\n\n

The Nobel Prize in Chemistry 2020. Al\u0131nd\u0131\u011f\u0131 yer:<\/em><\/p>\n\n\n\n

https:\/\/www.nobelprize.org\/prizes\/chemistry\/2020\/press-release\/<\/a><\/p>\n\n\n\n

The Nobel Prize in Chemistry 2020. Al\u0131nd\u0131\u011f\u0131 yer:<\/em><\/p>\n\n\n\n

https:\/\/www.nobelprize.org\/prizes\/chemistry\/2020\/summary\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

2020 Nobel Kimya \u00d6d\u00fcl\u00fc, genom kurgulamas\u0131na olanak sa\u011flayan \u00e7al\u0131\u015fmalar y\u00fcr\u00fcten mikrobiyolog Emmanuelle Charpentier ile biyokimyac\u0131 Jennifer A. Doudna’ya verildi. DNA<\/p>\n","protected":false},"author":266,"featured_media":7940,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[1188,73,1191,1192,1190,1189,1193],"acf":[],"views":2160,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/7934"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/266"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=7934"}],"version-history":[{"count":1,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/7934\/revisions"}],"predecessor-version":[{"id":7941,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/7934\/revisions\/7941"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/7940"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=7934"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=7934"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=7934"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}