{"id":8317,"date":"2020-11-11T18:40:19","date_gmt":"2020-11-11T15:40:19","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=8317"},"modified":"2020-11-11T18:40:22","modified_gmt":"2020-11-11T15:40:22","slug":"kemoterapinin-kesfine-dair-jane-cooke-wright","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/kemoterapinin-kesfine-dair-jane-cooke-wright\/","title":{"rendered":"KEMOTERAP\u0130N\u0130N KE\u015eF\u0130NE DA\u0130R: JANE COOKE WRIGHT"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Jane Cooke Wright, 20\nKas\u0131m 1919 tarihinde Amerika\u2019da do\u011fmu\u015ftur. \u00d6nc\u00fc bir kanser ara\u015ft\u0131rmac\u0131s\u0131 ve\nkemoterapiye katk\u0131 sa\u011flam\u0131\u015f bir hekimdir. Wright, potansiyel ila\u00e7lar\u0131n kanser\nh\u00fccreleri \u00fczerindeki etkilerini test etmek i\u00e7in laboratuvar fareleri yerine\ninsan doku k\u00fclt\u00fcr\u00fcn\u00fc kullanma tekni\u011fini geli\u015ftirmesiyle tan\u0131n\u0131r. Ayr\u0131ca meme\nkanseri ve cilt kanserini tedavi etmek i\u00e7in metotreksat <\/em>ilac\u0131n\u0131n\nkullan\u0131m\u0131na da \u00f6nc\u00fcl\u00fck etmi\u015ftir.<\/p>\n\n\n\n

\"\"

Jane Wright ve k\u0131z karde\u015fi Barbara Wright Pierce <\/figcaption><\/figure>\n\n\n\n

Wright\u2019\u0131n annesi \u00f6\u011fretmen\nCorinne Cooke\u2019dur. Babas\u0131 ise Doktor Louis Tompkins Wright\u2019t\u0131r. Jane’in ailesinin\nt\u0131p alan\u0131nda g\u00fc\u00e7l\u00fc ba\u015far\u0131 hikayeleri vard\u0131r. Babas\u0131 Dr. Louis, Harvard\n\u00dcniversitesi T\u0131p Fak\u00fcltesi’nden doktorluk derecesi alm\u0131\u015f ve New York City’deki\nbir devlet hastanesinde \u00e7al\u0131\u015fm\u0131\u015f ilk Afrikal\u0131 doktordur. Babas\u0131 Harlem\nHastanesi’nde \u00e7al\u0131\u015ft\u0131\u011f\u0131 30 y\u0131lda Harlem Hastanesi Kanser Ara\u015ft\u0131rma Vakf\u0131’n\u0131 kurmu\u015f\nve y\u00f6netmi\u015ftir. Jane Wright ve k\u0131z karde\u015fi Barbara Wright Pierce de mesleki\nhayatlar\u0131nda babalar\u0131n\u0131n ve b\u00fcy\u00fckbabalar\u0131n\u0131n ayak izlerini takip ederek hem\ncinsiyet hem de \u0131rksal \u00f6n yarg\u0131lar\u0131n \u00fcstesinden gelmi\u015f, o d\u00f6nemlerdeki tabular\u0131\ny\u0131karak mesleklerinde ba\u015far\u0131l\u0131 olmu\u015flard\u0131r.<\/p>\n\n\n\n

Peki Jane\u2019in hikayesi\nnas\u0131l ba\u015flad\u0131? Dilerseniz kemoterapinin geli\u015fimine \u00f6nc\u00fcl\u00fck etmi\u015f bu bilim\ninsan\u0131n hayat hikayesine daha yak\u0131ndan g\u00f6z atal\u0131m. <\/p>\n\n\n\n

Jane, ba\u015flang\u0131\u00e7ta sanat\nalan\u0131nda bir derece yapmak istemi\u015ftir. Bu y\u00fczden Smith Koleji’ne gitmi\u015ftir. Smith\nKoleji’ndeki e\u011fitiminin ard\u0131ndan babas\u0131n\u0131n k\u0131lavuzlu\u011fuyla, New York T\u0131p Fak\u00fcltesi’nde,\ntam burslu olarak t\u0131p e\u011fitimine ba\u015flam\u0131\u015ft\u0131r. 1945’te s\u0131n\u0131f birincisi olarak\nonur \u00f6d\u00fcl\u00fc ile mezun olmu\u015ftur. T\u0131p fak\u00fcltesinden mezun olduktan sonra Dr.\nWright, Bellevue Hastanesi’nde bir y\u0131l staj yapm\u0131\u015ft\u0131r. 1947 y\u0131l\u0131nda Avukat\nDavid D. Jones Jr. ile evlenmi\u015ftir. 1949\u2019da ise Harlem Hastanesi’nde ba\u015f\nasistan olarak cerrahi ihtisas\u0131n\u0131 tamamlam\u0131\u015ft\u0131r. Sonras\u0131nda babas\u0131n\u0131n kurdu\u011fu\nHarlem Hastanesi Kanser Ara\u015ft\u0131rma Merkezi’ndeki ara\u015ft\u0131rmalara kat\u0131lm\u0131\u015ft\u0131r. Ara\u015ft\u0131rma\nEnstit\u00fcs\u00fc\u2019nde ge\u00e7irdi\u011fi s\u00fcre boyunca, Jane ve babas\u0131 kemoterap\u00f6tik ajanlarla\nilgili \u00e7al\u0131\u015fmalar yapm\u0131\u015flard\u0131r. O d\u00f6nemlerde, kemoterapi yeni bir tedavi\ny\u00f6ntemi olmas\u0131ndan dolay\u0131 iyi bilinen veya iyi uygulanan bir kaynak olarak g\u00f6r\u00fclmemekteydi. Ancak Jane\nve babas\u0131 Louis kemoterapiyi kanser tedavisi i\u00e7in \u00f6nemli bir basamak olarak\ng\u00f6rmekteydiler. Onlar kemoterapi tedavisini herkes i\u00e7in daha eri\u015filebilir\nk\u0131lmay\u0131 ama\u00e7lam\u0131\u015f ve nitekim bu konuda da ba\u015far\u0131l\u0131 olmu\u015flard\u0131r.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Folik asit antagonistleri, h\u00fccrelerin belirli amino asitleri \u00fcretmesi i\u00e7in gerekli bir koenzim olan folik asiti bloke eder. B\u00f6ylece h\u00fccreler yeni DNA ve RNA zincirleri olu\u015fturamaz veya mitozu tetikleyecek proteinleri \u00fcretemezler. Kanserli dokularda kontrols\u00fcz h\u00fccre b\u00f6l\u00fcnmeleri ger\u00e7ekle\u015fti\u011fi i\u00e7in tedavide bu kontrols\u00fczl\u00fc\u011f\u00fc durdurmak \u00e7ok \u00f6nemlidir. Jane ve babas\u0131 taraf\u0131ndan \u00fczerinde \u00e7al\u0131\u015f\u0131lan folik asit antagonistleri kanser \u00fczerine yap\u0131lan en \u00f6nemli \u00e7al\u0131\u015fmalardan biridir. Antifolatlar; L\u00f6semi, Hodgkin hastal\u0131\u011f\u0131, Lenfosarkom, Melanom, Meme kanseri ve Prostat kanseri gibi kanser t\u00fcrlerinde tedavide kullan\u0131lan etkili ila\u00e7lard\u0131r. Dr. Jane, Antifolat ila\u00e7 grubunda yer alan ve tedavide s\u0131kl\u0131kla kullan\u0131lan Metotreksat<\/em>\u2019\u0131n kanser hastal\u0131\u011f\u0131na kar\u015f\u0131 etkili bir ila\u00e7 oldu\u011funu kan\u0131tlam\u0131\u015ft\u0131r. Bu ke\u015fif ile kemoterapiyi denenmemi\u015f, deneysel varsay\u0131msal bir tedavi alan\u0131ndan test edilmi\u015f, etkinli\u011fi kan\u0131tlanm\u0131\u015f kanser terap\u00f6tikleri alan\u0131na ta\u015f\u0131m\u0131\u015ft\u0131r. <\/p>\n\n\n\n

G\u00fcn\u00fcm\u00fczde Metotreksat<\/em> ilac\u0131 bir\u00e7ok kanser t\u00fcr\u00fcn\u00fc tedavi etmek i\u00e7in kullan\u0131lan ba\u015fl\u0131ca kemoterapi ila\u00e7lar\u0131ndan biridir ve modern kemoterapinin temelini olu\u015fturmu\u015ftur.<\/p>\n\n\n\n

Wright kemoterap\u00f6tiklerde kombinatoryal \u00e7al\u0131\u015fmalara \u00f6nc\u00fcl\u00fck ederek, yaln\u0131zca birden fazla ilac\u0131n uygulanmas\u0131na de\u011fil, kemoterapinin etkinli\u011fini art\u0131rmak ve yan etkileri en aza indirmek i\u00e7in s\u0131ral\u0131 ve dozaj varyasyonlar\u0131na odaklanm\u0131\u015ft\u0131r. Cilt kanseri hastalar\u0131n\u0131n ya\u015fam s\u00fcrelerini on y\u0131la kadar art\u0131ran bir kemoterapi protokol\u00fc geli\u015ftirmi\u015ftir. Ayr\u0131ca karaci\u011fer ve dalakta bulunan t\u00fcm\u00f6rlerde etkili ila\u00e7lar\u0131n hastaya uygulanmas\u0131 amac\u0131yla yeni bir kateter giri\u015fim y\u00f6ntemi kullanm\u0131\u015ft\u0131r. <\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Jane Cooke Wright, kariyeri\nboyunca kanser kemoterap\u00f6tikleri \u00fczerine 100’den fazla makale yay\u0131nlam\u0131\u015f ve\nJournal of the National Medical Association’\u0131n yay\u0131n kurulunda g\u00f6rev yapm\u0131\u015ft\u0131r.\n1964’te, Amerikan Klinik Onkoloji Derne\u011fi’nin kurulmas\u0131na \u00f6nc\u00fcl\u00fck eden yedi\ndoktor aras\u0131ndaki tek kad\u0131nd\u0131r ve 1971’de New York Kanser Derne\u011fi’nin\nba\u015fkanl\u0131\u011f\u0131na se\u00e7ilmi\u015ftir. <\/p>\n\n\n\n

Dr. Jane, 19\n\u015eubat 2013 tarihinde aram\u0131zdan ayr\u0131lm\u0131\u015ft\u0131r. Geride b\u0131rakt\u0131\u011f\u0131 en b\u00fcy\u00fck miras\u0131\nbir\u00e7ok insan\u0131n hayat\u0131na dokunan, onlara umut olan kemoterapiye dair yapt\u0131\u011f\u0131\nke\u015fiflerdir.<\/p>\n\n\n\n

KAYNAKLAR:<\/em><\/h4>\n\n\n\n

Jane C. Wright – Jane C.\nWright. Al\u0131nd\u0131\u011f\u0131 yer:<\/em><\/h4>\n\n\n\n

https:\/\/tr.qaz.wiki\/wiki\/Jane_C._Wright<\/a><\/p>\n\n\n\n

CANCER CHEMOTHERAPY: PAST, PRESENT AND FUTURE. Al\u0131nd\u0131\u011f\u0131 yer:<\/em><\/h4>\n\n\n\n

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2609825\/pdf\/jnma00464-0023.pdf<\/a><\/p>\n\n\n\n

Dr. Jane Cooke Wright.\nAl\u0131nd\u0131\u011f\u0131 yer:<\/em><\/h4>\n\n\n\n

https:\/\/cfmedicine.nlm.nih.gov\/physicians\/biography_336.html<\/a><\/p>\n\n\n\n

Mustard grubu kimyasal\nsava\u015f ajanlar\u0131 ve klinik etkileri. Al\u0131nd\u0131\u011f\u0131 yer:<\/em><\/h4>\n\n\n\n

https:\/\/dergipark.org.tr\/tr\/pub\/sagakaderg\/issue\/46723\/586005<\/a><\/p>\n\n\n\n

A passion for Solving the Puzzle of Cancer: Jane Cooke Wright, M.D., 1919-2013. <\/em><\/h4>\n\n\n\n

https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4063385\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Jane Cooke Wright, 20 Kas\u0131m 1919 tarihinde Amerika\u2019da do\u011fmu\u015ftur. \u00d6nc\u00fc bir kanser ara\u015ft\u0131rmac\u0131s\u0131 ve kemoterapiye katk\u0131 sa\u011flam\u0131\u015f bir hekimdir. Wright,<\/p>\n","protected":false},"author":266,"featured_media":8323,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[1331,55,133,1332,1333],"acf":[],"views":786,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/8317"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/266"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=8317"}],"version-history":[{"count":2,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/8317\/revisions"}],"predecessor-version":[{"id":8326,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/8317\/revisions\/8326"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/8323"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=8317"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=8317"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=8317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}