{"id":8547,"date":"2020-11-20T12:12:33","date_gmt":"2020-11-20T09:12:33","guid":{"rendered":"http:\/\/blog.ulubat.org\/?p=8547"},"modified":"2020-11-20T12:12:36","modified_gmt":"2020-11-20T09:12:36","slug":"meme-kanserinde-yeni-bir-cigir-bal-arilari","status":"publish","type":"post","link":"https:\/\/blog.ulubat.org\/index.php\/genel\/meme-kanserinde-yeni-bir-cigir-bal-arilari\/","title":{"rendered":"Meme Kanserinde Yeni Bir \u00c7\u0131\u011f\u0131r: Bal Ar\u0131lar\u0131"},"content":{"rendered":"\n
\"\"<\/figure><\/div>\n\n\n\n

Ge\u00e7ti\u011fimiz \u201cPembe Ekim\u201d meme kanseri fark\u0131ndal\u0131k ay\u0131yd\u0131. Ben\nde bu ayki yaz\u0131mda meme kanseri ve bal ar\u0131lar\u0131 ile ilgili yeni yay\u0131nlanm\u0131\u015f,\nbeni \u00e7ok heyecanland\u0131ran bu ara\u015ft\u0131rmadan sizleri de haberdar etmek istedim .<\/p>\n\n\n\n

Peki nedir bu \u00e7o\u011fu\nkad\u0131n\u0131m\u0131zda g\u00f6r\u00fclen meme kanseri?<\/strong><\/p>\n\n\n\n

 K\u0131saca inceleyecek\nolursak; meme kanseri, meme dokusu i\u00e7indeki s\u00fct kanallar\u0131nda olu\u015fan kanser\nh\u00fccreleridir. Daha \u00e7ok 50-60 ya\u015flar\u0131nda ortaya \u00e7\u0131kt\u0131\u011f\u0131 g\u00f6sterilse de T\u00fcrkiye\u2019de\n50 ya\u015f alt\u0131 n\u00fcfusta da g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 artm\u0131\u015ft\u0131r. Meme kanserlerinin %80\u2019i\ninvaziv duktal karsinom olup s\u00fct kanallar\u0131nda geli\u015firken %20\u2019si ise invaziv lob\u00fcler\nkarsinom olup s\u00fct bezlerinden geli\u015fir. Toplumda bu kadar s\u0131k g\u00f6r\u00fclmesi, \u00fczerinde\n\u00e7ok\u00e7a ara\u015ft\u0131rma yap\u0131lmas\u0131na neden olmu\u015ftur. Bug\u00fcn bu ara\u015ft\u0131rmalardan biriyle\nsizlerleyim.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Bat\u0131 Avustralya\u2019da bulunan Harry Perkins T\u0131bbi Ara\u015ft\u0131rma Enstit\u00fcs\u00fc\u2019nde Ciara Duffy\u2019un doktoras\u0131n\u0131n bir par\u00e7as\u0131 olarak ger\u00e7ekle\u015ftirilen bir ara\u015ft\u0131rmada bal ar\u0131s\u0131 zehrinin meme kanseri h\u00fccrelerini yok etti\u011fi ortaya \u00e7\u0131kar\u0131ld\u0131. Bal ar\u0131lar\u0131 taraf\u0131ndan \u00fcretilen bal, polen, ar\u0131 s\u00fct\u00fc, propolis y\u0131llard\u0131r t\u0131bbi olarak kullan\u0131lan \u00fcr\u00fcnlerdir. Bal ar\u0131s\u0131 zehrinin kuru a\u011f\u0131rl\u0131\u011f\u0131n\u0131n yar\u0131s\u0131n\u0131 melittin olu\u015fturmaktad\u0131r. Melittin 26 aminoasitli, h\u00fccre zarlar\u0131nda g\u00f6zenekler olu\u015fturarak dakikalar i\u00e7erisinde par\u00e7alanmas\u0131na neden olan bir polipeptittir. Pek \u00e7ok zehrin kanserleri hedef ald\u0131\u011f\u0131 bilinse de altta yatan molek\u00fcler mekanizma hala kafa kar\u0131\u015ft\u0131r\u0131c\u0131yd\u0131.<\/p>\n\n\n\n

Pek \u00e7ok zehir, kanserleri hedef al\u0131rken ar\u0131 zehri\nneden belli bir kanseri hedef als\u0131n ki?<\/strong><\/p>\n\n\n\n

Bu d\u00fc\u015f\u00fcnce ekibin kafas\u0131n\u0131 fazlaca kurcalamaya ba\u015flad\u0131\u011f\u0131 i\u00e7in bununla ilgili \u00e7al\u0131\u015fmalar yap\u0131lmaya ba\u015fland\u0131. Bal ar\u0131lar\u0131 d\u00fcnyan\u0131n \u00e7e\u015fitli yerlerinden toplanarak par\u00e7aland\u0131 ve melittin sentezlendi. Bunu takip eden \u00e7al\u0131\u015fmalarda normal benzeri h\u00fccrelerin h\u00fccresel yan\u0131t\u0131 test edilerek bal ar\u0131s\u0131 ve melittinin antikanser \u00f6zellikleri de\u011ferlendirildi. Elde edilen sonu\u00e7larda bal ar\u0131s\u0131 zehri ve melittinin, TNBC (Triple-Negative Breast Cancer) ve HER2 ile zenginle\u015ftirilmi\u015f meme kanseri h\u00fccrelerinin canl\u0131l\u0131\u011f\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131 g\u00f6zlendi. Ayn\u0131 zamanda membran bozulmas\u0131 ve kaspaz 3 arac\u0131l\u0131 apoptoz yoluyla h\u00fccre \u00f6l\u00fcm\u00fcn\u00fcnde de etkisi g\u00f6zlendi. Melittinin; primer olarak EGFR ve HER2’nin aktivasyonunu inhibe ederek meme kanseri h\u00fccrelerinde a\u015fa\u011f\u0131 ak\u0131\u015f onkojenik Akt ve MAPK sinyal yollar\u0131n\u0131 mod\u00fcle etti\u011fi a\u00e7\u0131kland\u0131. B\u00f6ylece melittinin, kanser h\u00fccrelerinin plazma membran\u0131nda a\u015f\u0131r\u0131 eksprese edilen aktive edilmi\u015f resept\u00f6rlerin dimerizasyonunu, birli\u011fini ve\/veya aktivitesini bozdu\u011funu ve b\u00f6ylece a\u015fa\u011f\u0131 ak\u0131\u015f aktivitesini inhibe etti\u011fi tahmin edildi. <\/p>\n\n\n\n

\u00d6ncelikle negatif y\u00fckl\u00fc \u201cDEDE-mellitin\u201d peptidi sentezlenerek peptid m\u00fchendisli\u011fiyle melittin y\u00fck\u00fc de\u011fi\u015ftirildi. Bu kanser h\u00fccrelerinde melittin aktivitesi ortadan kald\u0131r\u0131larak pozitif y\u00fck\u00fcn anti-neoplastik etki i\u00e7in gerekli oldu\u011fu, ayr\u0131ca olu\u015fan peptidin kanser h\u00fccrelerine kar\u015f\u0131 daha se\u00e7ici oldu\u011fu g\u00f6sterildi. <\/p>\n\n\n\n

\"\"
Mellitin peptit toksini; Apitoksinin (bal ar\u0131s\u0131 zehri) ana bile\u015fenidir.<\/figcaption><\/figure><\/div>\n\n\n\n

Melittin h\u00fccre zarlar\u0131nda g\u00f6zenekler olu\u015fturdu\u011fundan h\u00fccrelere kemoterapilerin veya k\u00fc\u00e7\u00fck molek\u00fcllerin giri\u015fini kolayla\u015ft\u0131rabilece\u011fini aksi takdirde t\u00fcm\u00f6r varl\u0131\u011f\u0131nda \u00f6zellikle de in vivo olarak iletilmesi zor olabilece\u011fi varsay\u0131m\u0131nda bulunuldu. Bu nedenle, in vivo<\/em> bir TNBC allogreft fare modelinde melittin tedavisi Dosetaksel (kemoterapi ilac\u0131) tedavisi ile birle\u015ftirildi ve bu kombinasyonun kanser h\u00fccresi proliferasyonunu ve t\u00fcm\u00f6r b\u00fcy\u00fcmesini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131 ke\u015ffedildi. \u0130lgin\u00e7 bir \u015fekilde t\u00fcm\u00f6rlerde  PD-L1(the levels of the immune-checkpoint protein programmed death ligand-1) seviyeleri de melittin taraf\u0131ndan azalt\u0131ld\u0131. Melittin bu nedenle kemoterapi varl\u0131\u011f\u0131nda TNBC’lerde yayg\u0131n olan t\u00fcm\u00f6r mikro ortam\u0131n\u0131n imm\u00fcn bask\u0131lay\u0131c\u0131 etkilerini azaltabilir. Meme kanserlerinin ba\u011f\u0131\u015f\u0131kl\u0131k tedavilerine daha iyi yan\u0131t vermesine yard\u0131mc\u0131 olabilecek, melittin ile ba\u011f\u0131\u015f\u0131kl\u0131k tepkilerinin g\u00fc\u00e7lendirilmesi i\u00e7in \u00e7al\u0131\u015fmalar hala devam etmektedir. <\/p>\n\n\n\n

Yap\u0131lan \u00e7al\u0131\u015fmalar bu uzun soluklu yolculu\u011fun hen\u00fcz daha ba\u015flang\u0131c\u0131d\u0131r. \u0130nsan denemelerinden \u00f6nce, maksimum tolere edilen dozlar\u0131 ve toksisiteleri resmi olarak de\u011ferlendirmek i\u00e7in daha bir\u00e7ok deneye ihtiya\u00e7 duyulmaktad\u0131r. \u015eu ana kadar yap\u0131lan \u00e7al\u0131\u015fmalara genel olarak g\u00f6z atacak olursak elde etti\u011fimiz bu bulgular bal ar\u0131s\u0131 ve melittinin meme kanseri h\u00fccre ya\u015fanabilirli\u011fini h\u0131zl\u0131 ve g\u00fc\u00e7l\u00fc bir \u015fekilde azaltt\u0131\u011f\u0131n\u0131 g\u00f6sterirken ayn\u0131 zamanda meme kanserinin olduk\u00e7a agresif alt tiplerinin tedavisi i\u00e7in de kemoterapiler veya di\u011fer k\u00fc\u00e7\u00fck molek\u00fcllerle beraber kullan\u0131labilece\u011fini ortaya koymu\u015ftur.<\/p>\n\n\n\n

.<\/p>\n\n\n\n

.<\/p>\n\n\n\n

KAYNAK\u00c7A:\n<\/p>\n\n\n\n

1.<\/strong>Duffy, C.,vd. (1 September 2020). Honeybee venom and melittin\nsuppress growth factor resept\u00f6r activation in HER2-enriched and triple negative\nbreast cancer. npc Precision Oncology. <\/em>Article number:24. (https:\/\/www.nature.com\/articles\/s41698-020-00129-0<\/a>)<\/p>\n\n\n\n

2.<\/strong>https:\/\/cancercommunity.nature.com\/posts\/honeybee-venom-in-breast-cancer-treatment-behind-the-paper<\/a><\/p>\n\n\n\n

3<\/strong>.BBC. \u201cHoneybee venom kills some breast cancer cell\u201d (Last\nupdate: 2 September 2020)  https:\/\/www.bbc.com\/news\/world-australia-53994058<\/a><\/p>\n\n\n\n

4.<\/strong>T.C. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Halk Sa\u011fl\u0131\u011f\u0131 Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc Kanser\nDairesi Ba\u015fkanl\u0131\u011f\u0131 https:\/\/hsgm.saglik.gov.tr\/tr\/kanser-turleri\/kanser-turleri\/meme-kanseri.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Bal ar\u0131s\u0131 ve melittin, meme kanseri h\u00fccre ya\u015fanabilirli\u011fini h\u0131zl\u0131 ve g\u00fc\u00e7l\u00fc bir \u015fekilde azalt\u0131r. Ayr\u0131ca meme kanserinin agresif alt tiplerinin tedavisi i\u00e7in de kemoterapiler ve di\u011fer k\u00fc\u00e7\u00fck molek\u00fcllerle beraber kullan\u0131labilir.<\/p>\n","protected":false},"author":387,"featured_media":8553,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[1420,1414,1421,1417,1415,1413,1416,1419,55,133],"acf":[],"views":862,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/8547"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/387"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=8547"}],"version-history":[{"count":7,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/8547\/revisions"}],"predecessor-version":[{"id":8562,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/8547\/revisions\/8562"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/8553"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=8547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=8547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=8547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}