![\"\"](\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2020\/12\/ssss-1024x1024.png\")
<\/figure><\/div>\n\n\n\nAncak NIH\u2019teki ara\u015ft\u0131rmac\u0131lar bu bilginin do\u011frulu\u011funu\nsorgulatacak veriler elde etti. <\/p>\n\n\n\n
\u00d6zellikle 2016\u2019dan beri G\u00fcney Afrika ba\u015fta olmak \u00fczere pek \u00e7ok \u00fclkede salg\u0131nlara yol a\u00e7an zika vir\u00fcs\u00fc tedavisi i\u00e7in geni\u015f \u00e7apta bir ila\u00e7 taramas\u0131 yapan ara\u015ft\u0131rmac\u0131lar tetrasiklin t\u00fcrevi bir antibiyotik olan metasiklinin i\u015fe yarad\u0131\u011f\u0131na dair sonu\u00e7lara ula\u015ft\u0131. <\/p>\n\n\n\n
Bilindi\u011fi gibi zika vir\u00fcs\u00fc; flavivir\u00fcs cinsinden, tek zincirli bir RNA vir\u00fcs\u00fcd\u00fcr. Vir\u00fcsle enfekte olan \u00e7o\u011fu ki\u015fi bu s\u00fcreci asemptomatik ge\u00e7irse de baz\u0131 ki\u015filer i\u00e7in hastal\u0131k \u00f6l\u00fcmc\u00fcl olabilir. Hatta gebelerde plasenta bariyerini a\u015f\u0131p fet\u00fcs\u00fc enfekte edebilir. Bebek bu nedenle mikrosefali ve di\u011fer konjenital anomalilere sahip bir \u015fekilde do\u011fabilir. \u00d6zellikle gebeli\u011fin ilk 3 ay\u0131nda bu risk \u00e7ok y\u00fcksektir. Vir\u00fcs ayn\u0131 zamanda Guillain Barre sendromu riskini de art\u0131rmaktad\u0131r. <\/p>\n\n\n\n
![\"\"](\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2020\/12\/88331798_88331797-1024x1024.jpg\")
Vir\u00fcs, t\u0131pk\u0131 di\u011fer RNA vir\u00fcsleri gibi enfekte etti\u011fi h\u00fccreye\nRNA\u2019s\u0131n\u0131 salar. \u0130stila edilmi\u015f h\u00fccre de RNA\u2019n\u0131n kodlad\u0131\u011f\u0131 proteinleri sentezler.\nBu sayede yeni vir\u00fcsler \u00fcretilir ve \u00e7o\u011falma sa\u011flan\u0131r. <\/p>\n\n\n\n
Bilim insanlar\u0131n\u0131n dikkat etti\u011fi \u015fey ise bu proteinlerin ilk ba\u015fta birbirine ba\u011fl\u0131 bir \u015fekilde \u00fcretilip daha sonra \u201cNS2B-NS3 proteaz\u201d adl\u0131 enzim taraf\u0131ndan birbirinden ayr\u0131larak i\u015flev kazanmas\u0131yd\u0131. Bu enzimin inhibisyonuyla proteinlerin aktifle\u015femeyece\u011fini, sonu\u00e7ta da vir\u00fcs\u00fcn \u00e7o\u011falamayaca\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcler ve bu enzimi inhibe edebilecek ila\u00e7lar\u0131 geni\u015f bir spektrumda incelemeye ald\u0131lar. <\/p>\n\n\n\n
![\"\"](\"https:\/\/blog.ulubat.org\/wp-content\/uploads\/2020\/12\/Zika_genome-1024x1024.png\")
Hem FDA onayl\u0131 olmas\u0131 hem de plasentadan ge\u00e7ebilmesi, ayr\u0131ca etki mekanizmas\u0131n\u0131n da belirlenen stratejiye uygun olmas\u0131 nedeniyle tetrasiklin grubu \u00fczerine yo\u011funla\u015ft\u0131lar. Oral yoldan kullan\u0131labilir olmas\u0131 da bu grubun bir di\u011fer avantaj\u0131yd\u0131. <\/p>\n\n\n\n
K\u00fc\u00e7\u00fck bir not: Tetrasiklin grubu antibiyotikler ribozomlar\u0131n\n30-S alt \u00fcnitelerine ba\u011flan\u0131r ve t-RNA\u2019lar\u0131n buraya ba\u011flanmas\u0131n\u0131 engelleyerek\nprotein sentezini inhibe ederler. <\/p>\n\n\n\n
Petri kab\u0131ndaki n\u00f6ronal k\u00f6k h\u00fccreler \u00fczerinde yap\u0131lan deneylerde metasiklinin bu h\u00fccrelerdeki zika vir\u00fcs\u00fc enfeksiyonunu azaltt\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc. Zika vir\u00fcs\u00fcyle enfekte edilmi\u015f fare modellerinde de ilac\u0131n, vir\u00fcs kaynakl\u0131 motor bozukluklar\u0131 azaltt\u0131\u011f\u0131 g\u00f6zlemlendi. Ancak yine de enfeksiyonu tamam\u0131yla \u00f6nleyemedi. <\/p>\n\n\n\n
Fare modellerini detayland\u0131r\u0131rsak Zika vir\u00fcs ile enfekte modellerde uzuvlarda sertlik, tremor, dik durmada zorlanma, denge kayb\u0131, flask paralizi, n\u00f6betler ve kilo kayb\u0131 g\u00f6zlendi. Beynin histolojik incelemesinde ise gliozis, kortikal ve purkinje n\u00f6ronlar\u0131n\u0131n kayb\u0131 g\u00f6r\u00fcld\u00fc. Kan damarlar\u0131nda geni\u015fleme, vakuolasyon, inflamatuar h\u00fccre infiltrasyonu g\u00f6zlemlenen di\u011fer bulgulard\u0131. <\/p>\n\n\n\n
Metasiklinle tedavi edilmi\u015f farelerde ise beyinde zika vir\u00fcs enfeksiyonu azald\u0131 ve zika vir\u00fcs taraf\u0131ndan ind\u00fcklenmi\u015f motor defisitlerin \u015fiddeti azald\u0131. Ancak enfekte hayvanlardaki kilo kayb\u0131 \u00f6nlenemedi. G\u00f6vde kontrol yetene\u011fi, s\u0131rt \u00fcst\u00fc \u00e7evrildi\u011finde geri d\u00f6nme s\u00fcresi, metasiklin ile tedavi edilen farelerde \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirildi. Bu hayvanlar\u0131n beyni incelendi\u011finde vir\u00fcse ait \u00e7ok\u00e7a RNA ve protein bulundu. Beynin pek \u00e7ok b\u00f6lgesinde zika vir\u00fcse ait protein ekspresyonu azald\u0131. Serebellar purkinje h\u00fccrelerinde ise bir miktar kay\u0131p oldu\u011fu g\u00f6r\u00fcld\u00fc. Metasiklin tedavisi ise kontrol grubundaki enfekte edilmemi\u015f farelerin beyinlerinde bir hasara yol a\u00e7mad\u0131 ayr\u0131ca enfekte olmu\u015f fareleri de purkinje h\u00fccre kayb\u0131na kar\u015f\u0131 korudu.<\/p>\n\n\n\n
Tetrasiklin grubunun yan\u0131 s\u0131ra pek \u00e7ok ba\u015fka ilac\u0131n da denendi\u011fini s\u00f6ylemi\u015ftik. Yine bir antibiyotik olan Novobiosin de denenen ila\u00e7lar aras\u0131ndayd\u0131. Bu ila\u00e7 g\u00f6n\u00fcll\u00fclerden birinde bilirubin metabolizmas\u0131n\u0131 inhibe ederek sar\u0131l\u0131\u011fa yol a\u00e7t\u0131. Ayn\u0131 zamanda ciltte ra\u015flar, l\u00f6kopeni, gastrointestinal rahats\u0131zl\u0131k gibi genel yan etkiler ve nadir de olsa ciddi yan etkiler yaratt\u0131. <\/p>\n\n\n\n
\u00d6zellikle sestodlara etki eden bir antihelmintik olan Niklosamid de n\u00f6ronal k\u00f6k h\u00fccrelere kar\u015f\u0131 toksik etki g\u00f6sterdi. <\/p>\n\n\n\n
\u00d6yle g\u00f6r\u00fcn\u00fcyor ki zika vir\u00fcs\u00fc enfeksiyonu i\u00e7in umut vaat eden bu geli\u015fme tart\u0131\u015fmaya \u00e7ok a\u00e7\u0131k. Ancak bilimde her do\u011frunun zamanla de\u011fi\u015febilece\u011finin de bir kan\u0131t\u0131.<\/p>\n\n\n\n
Te\u015fekk\u00fcrler.<\/p>\n\n\n\n
KAYNAK\u00c7A<\/p>\n\n\n\n
- Abrams, R. P., Yasgar, A., & al, T. T. (2020). Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. PNAS<\/em>, 1-11.<\/li>
- \u015eahin, O., & Mihmanl\u0131, V. (2016). Zika Vir\u00fcs. Okmeydan\u0131 T\u0131p Dergisi<\/em>, 29-36.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"
Toplumumuzda sadece bakteriler \u00fczerinde etkili olan \u201cantibiyotik\u201d lerin \u00f6zellikle viral hastal\u0131klar i\u00e7in kullan\u0131lmas\u0131 \u015f\u00fcphesiz en b\u00fcy\u00fck yanl\u0131\u015flardan biridir ve diren\u00e7<\/p>\n","protected":false},"author":57,"featured_media":9237,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[1596,159],"acf":[],"views":455,"_links":{"self":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/9225"}],"collection":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/users\/57"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/comments?post=9225"}],"version-history":[{"count":2,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/9225\/revisions"}],"predecessor-version":[{"id":9241,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/posts\/9225\/revisions\/9241"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media\/9237"}],"wp:attachment":[{"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/media?parent=9225"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/categories?post=9225"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ulubat.org\/index.php\/wp-json\/wp\/v2\/tags?post=9225"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- \u015eahin, O., & Mihmanl\u0131, V. (2016). Zika Vir\u00fcs. Okmeydan\u0131 T\u0131p Dergisi<\/em>, 29-36.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"